C. elegans and Innate Immunity

The striking similarities between the innate defenses of vertebrates and invertebrates as well as the amenability of Caenorhabditis elegans for genetic analysis have made this free-living ground nematode a popular model system in the study of bacterial pathogenesis. Although genetic studies have brought new insights, showing the inducibility and pathogen-specificity of the immune response, there is still much to be discovered about the exact mechanisms underlying resistance to infection. In this study a different angle was adopted to study host–pathogen interactions in C. elegans. Given the dynamic nature of an immune response, the proteome of C. elegans was investigated at four different time-points (24, 48, 72, 96 h) after infection with S. typhi, S. typhi Ty21a, C. sakazakii and E. coli OP50 using SDS PAGE as a preliminary step to detect variation in the whole protein content.

P.Srinivasan, M.Sc., PGADMD. He has attended 15 conferences at national and international level and have published 2 papers.He is currently doing research in Proteomics at Bundelkhand University,UP,India.M.Rajalakshmi, M.Sc.,PGADMD.,(PhD).,She has attended more than 10 conferences and is doing PUFA research at Bharathiyar University,TN,India.