Cold Thermal Processing in the Spinal Cord | In Search of Therapeutic Targets for Cold Hyperesthesia

Paul Wrigley

ISBN 10: 3639103432 / ISBN 13: 9783639103434

Published by VDM Verlag Dr. Müller, 2010

About this Item

Cold Thermal Processing in the Spinal Cord | In Search of Therapeutic Targets for Cold Hyperesthesia | Paul Wrigley | Taschenbuch | Englisch | VDM Verlag Dr. Müller | EAN 9783639103434 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

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Bibliographic Details

• Title: Cold Thermal Processing in the Spinal Cord | In Search of Therapeutic Targets for Cold Hyperesthesia
• Publisher: VDM Verlag Dr. Müller
• Publication Date: 2010
• Language: English
• ISBN 10: 3639103432
• ISBN 13: 9783639103434
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing.