Combinatorial Chemistry : Synthesis and Application

Stephen R Wilson

ISBN 10: 047112687X / ISBN 13: 9780471126874

Published by Wiley Mär 1997, 1997

About this Item

Neuware - Als eines der ersten Bücher auf diesem Gebiet stellt dieses Werk eine komplette Übersicht über die kombinatorische Chemie dar - geschrieben von Experten und Erfindern dieser Technik. Es wird dem Chemiker helfen, Zeit und Geld zu sparen, indem ihm hier die Hintergrundinformationen der kombinatorischen Technik bereitgestellt werden zur Synthese von Tausenden oder Millionen von Verbindungen innerhalb kurzer Zeit.

Seller Inventory # 9780471126874

Bibliographic Details

• Title: Combinatorial Chemistry : Synthesis and Application
• Publisher: Wiley Mär 1997
• Publication Date: 1997
• Language: English
• ISBN 10: 047112687X
• ISBN 13: 9780471126874
• Binding: Buch
• Condition: Neu
• Dimensions: 240W x 161H x 20D millimeters 240 millimeters width by 161 millimeters height by 20 millimeters depth
• Weight: 595 grams

About this title

Synopsis

The new time-saving revolution in drug discovery.

Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation.

Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes:
* Concepts and terms of combinatorial chemistry
* Polymer-supported synthesis of organic compounds
* Macro beads as microreactors
* Solid-phase methods in combinatorial chemistry
* Encoded combinatorial libraries, including Rf-encoding of synthesis beads
* Strategies for combinatorial libraries of oligosaccharides
* Combinatorial libraries of peptides, proteins, and antibodies using biological systems.

While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

About the Author

Stephen R. Wilson is Professor of Chemistry at New York University. He is also founder and President of Sphere Biosystems, Inc., in New Jersey, a biotech company based on fullerene combinatorial chemistry technology.

Anthony W. Czarnik is Senior Director of Chemistry at IRORI Quantum Microchemistry in La Jolla, California, and formerly Director of BioOrganic Chemistry at Parke-Davis Pharmaceutical Research.