Combinatorial Chemistry Synthesis and Application

Wilson, Stephen R. (Editor)/ Czarnik, Anthony W. (Editor)

ISBN 10: 047112687X / ISBN 13: 9780471126874

Published by Wiley-Interscience, 1997

About this Item

1st edition. 288 pages. 9.50x6.50x0.50 inches. In Stock. Seller Inventory # x-047112687X

Bibliographic Details

Title: Combinatorial Chemistry Synthesis and ...

Publisher: Wiley-Interscience

Publication Date: 1997

Binding: Hardcover

Condition: Brand New

About this title

Synopsis:

The new time-saving revolution in drug discovery.

Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation.

Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes:
* Concepts and terms of combinatorial chemistry
* Polymer-supported synthesis of organic compounds
* Macro beads as microreactors
* Solid-phase methods in combinatorial chemistry
* Encoded combinatorial libraries, including Rf-encoding of synthesis beads
* Strategies for combinatorial libraries of oligosaccharides
* Combinatorial libraries of peptides, proteins, and antibodies using biological systems.

While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

From the Publisher:

This book explores the subject of combinatorial chemistry with particular emphasis on nonpeptide organic applications. The authors represent a cross-section of specialties and the book is suitable for newcomers as well as leaders in the field. It covers all the organic chemistry technology available at the time of writing and is the only book of its kind concerning the combinatorial chemistry field and its organic applications.