From Development to Degeneration and Regeneration of the Nervous System

Editor-Charles E. Ribak PhD; Editor-Carlos Aramburo de la Hoz Phd; Editor-Edward G. Jones PhD; Editor-Jorge A. Larriva Sahd PhD; Editor-Larry W. Swanson PhD

ISBN 10: 0195369009 / ISBN 13: 9780195369007

Published by Oxford University Press, USA, 2008

About this Item

Hardbound with glossy pictorial cover. New with mild surface wear.

Seller Inventory # 26500ax

Bibliographic Details

• Title: From Development to Degeneration and Regeneration of the Nervous System
• Publisher: Oxford University Press, USA
• Publication Date: 2008
• Language: English
• ISBN 10: 0195369009
• ISBN 13: 9780195369007
• Binding: Hardcover
• Condition: New
• Weight: 25 ounces

About this title

Synopsis

This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortext. This description of cortical development also includes a discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, the hypothalamus. The remaining chapters of this section examine the clinical relevance of brain development in certain disease states in humans: neural tube defects and the normal and abnormal development of human electroencephalographic recordings during the first year of age.

The second section on degenerative disorders of the brain begins wtih details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters in this section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. Together, these chapters summarize much of our current knowledge about the major molecular and cellular changes found in several degenerative diseases of the brain.

The last section addresses the issues of brain plasticity and regeneration in the adult brain and begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. The following two chapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates. The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.

About the Author

Charles E. Ribak, PhD is in the Department of Anatomy and Neurobiology at UC Irvine. Carlos Arumbaro de la Hoz, PhD is at the Instituto de Neurobiología at Universidad Nacional Autónoma de México. Edward G. Jones, PhD, DPhil is Director, Center for Neuroscience at the University of California, Davis. Dr. Jorge A. Larriva Sahd is at the Instituto de Neurobiología at the Universidad Nacional Autónoma de México. Larry W. Swanson, PhD is with the Neuroscience Programme at the University of Southern California, Los Angeles CA.