Title: Formulation Development and Characterization of Nanosuspension: Nanosuspension Containing Risperidone
Publisher: LAP LAMBERT Academic Publishing
Publication Date: 2019
Language: English
ISBN 10: 6200306567
ISBN 13: 9786200306562
Binding: Soft cover
Condition: New

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Synopsis

This study was to identify and optimize formulation and process variables affecting characteristic and scale-up of nanosuspension manufacturing process on bead mill i.e media milling buttom down technique considering industrial perspective. Formulation factors evaluated were ratio of different polymer to drug and to beads. Whereas process parameters were milling bead concentration and stabilizer concentration. Responses measured in this study include zeta potential and mean particle size. The test revealed that ratio of polymer to drug have significant effect on zeta potential whereas variable milling bead concentration at constant milling speed and milling time have significant effect on the particle size distribution of nanosuspension. The X-ray powder diffraction pattern of drug milled at high and low speed reveals no form conversion when compared with unmilled drug. The formulated nanosuspension has shown a faster % cumulative release.

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