Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride : For Improved Efficacy Using Disintegrant Blends

Language: English

Published by LAP LAMBERT Academic Publishing, 2013

3659346047 / 9783659346040

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Recent advances in novel drug delivery system aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is fast dissolving tablets (FDT) of Phenylephrine Hydrochloride, a selective 1 adrenergic receptor antagonist, used for nasal decongestant and producing mydriasis effect. In present work an attempt has been made by formulating fast dissolving tablets of Phenylephrine Hydrochloride by superdisintegrants addition method using croscarmellose sodium, crospovidone and sodium starch glycolate. A total of 10 batches were prepared by using various combination and concentration of superdisintegrants and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release studies, kinetic studies and stability studies. Amongst all the formulations F2 and F9 were found to be better formulations which include single superdisintegrants and combination of superdisintegrants. Finally it was concluded that FDT of Phenylephrine Hydrochloride will be used as a novel drug dosage form for pediatrics and geriatrics.…

Seller Inventory # 9783659346040

Title
Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride : For Improved Efficacy Using Disintegrant Blends
Author
Vishal Chapla
Publisher
LAP LAMBERT Academic Publishing
Publication year
2013
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659346047
ISBN 13
9783659346040
Item weight
238 grams
Dimensions
220x150x10 mm

AHA-BUCH GmbH

Einbeck, Germany

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