Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride: For Improved Efficacy Using Disintegrant Blends

Chapla, Nikunj, Chapla, Vishal, Pujara, Naisarg

ISBN 10: 3659346047 / ISBN 13: 9783659346040

Published by LAP LAMBERT Academic Publishing, 2013

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Bibliographic Details

• Title: Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride: For Improved Efficacy Using Disintegrant Blends
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2013
• Language: English
• ISBN 10: 3659346047
• ISBN 13: 9783659346040
• Binding: paperback
• Condition: Like New
• Book Type: book

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Synopsis

Recent advances in novel drug delivery system aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is fast dissolving tablets (FDT) of Phenylephrine Hydrochloride, a selective α1 adrenergic receptor antagonist, used for nasal decongestant and producing mydriasis effect. In present work an attempt has been made by formulating fast dissolving tablets of Phenylephrine Hydrochloride by superdisintegrants addition method using croscarmellose sodium, crospovidone and sodium starch glycolate. A total of 10 batches were prepared by using various combination and concentration of superdisintegrants and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release studies, kinetic studies and stability studies. Amongst all the formulations F2 and F9 were found to be better formulations which include single superdisintegrants and combination of superdisintegrants. Finally it was concluded that FDT of Phenylephrine Hydrochloride will be used as a novel drug dosage form for pediatrics and geriatrics.

About the Author

Nikunj Chapla, completed Master of Pharmacy, Pharmaceutics from Department of Pharmaceutics, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences Deralakatte, Mangalore at NITTE University.