Formulation Of Phenytoin Complexes For Dissolution Enhancement: Inclusion Complexation Using -cyclodextrin And Hp -cyclodextrin

Maulika, Patel, Kalpen, Patel

ISBN 10: 3659537055 / ISBN 13: 9783659537059

Published by LAP LAMBERT Academic Publishing, 2014

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Bibliographic Details

• Title: Formulation Of Phenytoin Complexes For Dissolution Enhancement: Inclusion Complexation Using -cyclodextrin And Hp -cyclodextrin
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2014
• Language: English
• ISBN 10: 3659537055
• ISBN 13: 9783659537059
• Binding: paperback
• Condition: New
• Book Type: book

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Synopsis

Phenytoin Inclusion complex prepared by microwave method was used for preparation of FDT by different superdisintegrants by direct compression method. From that the cross-povidone (5%) containing inclusion complex was maximum DT, Wetting time and In-vitro drug release. The FDT containing 1:2 ratio complexes and 5% crospovidone give minimum DT and Wetting time. Then 32 full factorial designs were applied and the tablets were synthesized using different proportions of inclusion complex and crospovidone (%) by direct compression technique. The optimum ratio was 1:2 and 5% which produced highest DT (10.01 sec), Wetting time (9.45 sec.) and cumulative percent drug release (99.51% at 40 min). The solubility and dissolution pattern of Phenytoin were found to be carrier ratio dependent. From evaluation parameters and formulation characterization, it can be concluded that solubility of drug was improved by MW method compared to SE method and pure drug. The tablet contain optimum ratio of inclusion complex and optimum concentration of superdisintegrants give maximum drug release in minimum time period.

About the Author

Maulika S Patel, M. Pharmacy in Pharmaceutical Technology in Shree Krishna Institute of Pharmacy, Shankhalpur, becharaji at Gujarat Technological University, Ahmedabad, Gujarat, India.