Handbook of Assay Development in Drug Discovery: 5 (Drug Discovery Series)

Lisa K. Minor, Richard M. Eglen, Keith Houck, Philip E. Brandish, Stuart Emanuel, Zhuyin Li, Rob Hooft van Huijsduijnen, Dean Wenham, Richard Sportsman, Said A. Goueli, Martha O'Brien, Stephen K-F. Wong, David Powell, Nathalie Rouleau, Ralph J. Garippa, Ann F. Hoffman, Patricia Kasila, John Dunlop, Terry L. Riss, Priya Kunapuli, Qiang Lu, Susan M. Catalano, Carson Loomis, Dana L. Johnson, Inna Vainshtein, Robin L. Thurmond, Jeff Cook, Robert Graves, Patricia D. Pelton, Cailin Chen, Michele Dowless, Wayne Bocchinfuso, Kristen M. Borchert, Elaine J. Adie, Roger Bosse, Nathalie Bouchard, Conrad L. Cowan, Bruce Damiano, Michael J. Francis, Tina Garyantes, Dominique Perrin, Molly J. Price-Jones, Stephen Lin, Robert H. Oakley, Christine Hudson, C

ISBN 10: 1574444719 / ISBN 13: 9781574444711

Published by CRC Press 2006-01-20, 2006

About this Item

Seller Inventory # 6666-TNFPD-9781574444711

Bibliographic Details

• Title: Handbook of Assay Development in Drug Discovery: 5 (Drug Discovery Series)
• Publisher: CRC Press 2006-01-20
• Publication Date: 2006
• Language: English
• ISBN 10: 1574444719
• ISBN 13: 9781574444711
• Binding: Hardcover
• Condition: New

About this title

Synopsis

The need to screen targets faster and more efficiently, coupled with advances in parallel and multiplex chemical synthesis, has contributed to the increasing use of multiwell assays for drug discovery. The Handbook of Assay Development in Drug Discovery is a reference that describes the complete armament of tools currently available for performing various assay techniques.

Featuring contributions from assay developers in the pharmaceutical and vendor communities, the book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system, and troubleshooting tools. The handbook describes biochemical assay classes as well as non-class specific assay development for cell-based assays. It covers a wide range of target classes―including kinases, proteases, nuclear receptors, and GPCRs―and describes currently employed methods and assay types, such as radioligand binding assays, image analysis assays, enzyme fragment complementation, and bioluminescent and fluorescent-based assays.

Designed as a guide to running an assay from start to finish, the Handbook of Assay Development in Drug Discovery is an ideal bench top companion for discovery researchers, laboratory managers, academics, and other scientists involved in drug discovery screening, lead profiling, therapeutic target evaluation, and assay development and implementation in the pharmaceutical and biotechnology industries.

Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

About the Author

Lisa K. Minor