Liver Protection by Natural Means

Heba Handoussa

ISBN 10: 3659746290 / ISBN 13: 9783659746291

Published by LAP LAMBERT Academic Publishing Sep 2015, 2015

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -Due to the high interest in bioactive plant derived materials, hepatoprotective activity of the hydro-alcohol extract of Gentiana spicata (Gentianaceae) on carbon tetrachloride treated rats was investigated. This plant is common in the tropics and subtropics of both hemispheres. It is commonly used as folk medicine for treating stomach disorders, hypertension, renal colic, rheumatic pains, and for elimination of stones from the kidney and the ureters. Pre-treatment with gentiana extract significantly decreased alanine aminotransferase and aspartate aminotransferase enzymes, the major indicators of liver injury. In addition to, the capability of the extract to restore reduced glutathione depletion and to deplete reduced the level of thiobarbituric acid reactive substances. Furthermore, histopathological observation also showed an obvious amelioration in liver cell necrosis, liver lesions, and fatty changes. A new carboxygentisic acid (spicatic acid) was isolated as a first report in this study, besides flavonoids and catechins and their gallolyated derivatives. All structures were elucidated on the basis of conventional analytical methods.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 132 pp. Englisch.

Seller Inventory # 9783659746291

Bibliographic Details

• Title: Liver Protection by Natural Means
• Publisher: LAP LAMBERT Academic Publishing Sep 2015
• Publication Date: 2015
• Language: English
• ISBN 10: 3659746290
• ISBN 13: 9783659746291
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 9D millimeters 220 millimeters width by 150 millimeters height by 9 millimeters depth
• Weight: 215 grams

About this title

Synopsis

Due to the high interest in bioactive plant derived materials, hepatoprotective activity of the hydro-alcohol extract of Gentiana spicata (Gentianaceae) on carbon tetrachloride treated rats was investigated. This plant is common in the tropics and subtropics of both hemispheres. It is commonly used as folk medicine for treating stomach disorders, hypertension, renal colic, rheumatic pains, and for elimination of stones from the kidney and the ureters. Pre-treatment with gentiana extract significantly decreased alanine aminotransferase and aspartate aminotransferase enzymes, the major indicators of liver injury. In addition to, the capability of the extract to restore reduced glutathione depletion and to deplete reduced the level of thiobarbituric acid reactive substances. Furthermore, histopathological observation also showed an obvious amelioration in liver cell necrosis, liver lesions, and fatty changes. A new carboxygentisic acid (spicatic acid) was isolated as a first report in this study, besides flavonoids and catechins and their gallolyated derivatives. All structures were elucidated on the basis of conventional analytical methods.

About the Author

Dr. Heba Handoussa has a considerable experience in undergraduate teaching as a lecturer of Pharmaceutical Biology at German University in Cairo.In another focus area, she has extensive practice in plant metabolites analysis,mass spectrometers and spectroscopic techniques. Main author and reviewer of several published articles in reputable journals