Modulation of Mhc Antigen Expression and Disease

D. John Maudsley

ISBN 10: 0521499216 / ISBN 13: 9780521499217

Published by Cambridge University Press, 2005

About this Item

Druck auf Anfrage Neuware - Printed after ordering - The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumour and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression both in the aetiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumour rejection.

Seller Inventory # 9780521499217

Bibliographic Details

• Title: Modulation of Mhc Antigen Expression and Disease
• Publisher: Cambridge University Press
• Publication Date: 2005
• Language: English
• ISBN 10: 0521499216
• ISBN 13: 9780521499217
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 234W x 156H x 25D millimeters 234 millimeters width by 156 millimeters height by 25 millimeters depth
• Weight: 693 grams

About this title

Synopsis

The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.

Book Description

The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This text brings together basic aspects of the regulation of MHC antigens with important clinical applications.