Molecular Pathogenesis of Cholestasis

Peter L. M. Jansen

ISBN 10: 146134767X / ISBN 13: 9781461347675

Published by Springer US, Chapman And Hall/CRC, 2012

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Druck auf Anfrage Neuware - Printed after ordering - membrane contamination and thus could then be used to study transport function when pre pared as membrane vesicles. These approaches defined a number of transport functions in the plasma membranes of hepatocyres and ultimately led to the recognition that bile salts and 3 25 other solutes were transported into bile largely by ATP dependent transport mechanisms.2 - The advent ofmolecular cloning techniques and cellular expression systems rapidly acceler ated progress in this field and led to the molecular characterization ofmost ofthe major mem brane transport proteins that determine both the hepatic uptake of organic solutes as well as bile salt dependent and bile salt independent canalicular excretion. Overview of the Molecular Mechanisms of Bile Formation The major transporters that determine bile formation are illustrated in Figure 1 and are discussed in greater detail in the subsequent chapters. The enrerohepatic circulation ofbile salts maintains bile salt dependent bile flow. Bile salts are excreted into bile and are largely absorbed in the terminal ileum and then efficiently removed from the portal circulation at the basolateral plasma membrane of the heparocyte. Each of these steps is dependent on the function of bile salt transport proteins.

Seller Inventory # 9781461347675

Bibliographic Details

• Title: Molecular Pathogenesis of Cholestasis
• Publisher: Springer US, Chapman And Hall/CRC
• Publication Date: 2012
• Language: English
• ISBN 10: 146134767X
• ISBN 13: 9781461347675
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 248W x 165H x 21D millimeters 248 millimeters width by 165 millimeters height by 21 millimeters depth
• Weight: 652 grams

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Synopsis

membrane contamination and thus could then be used to study transport function when pre­ pared as membrane vesicles. These approaches defined a number of transport functions in the plasma membranes of hepatocyres and ultimately led to the recognition that bile salts and 3 25 other solutes were transported into bile largely by ATP dependent transport mechanisms.2 - The advent ofmolecular cloning techniques and cellular expression systems rapidly acceler­ ated progress in this field and led to the molecular characterization ofmost ofthe major mem­ brane transport proteins that determine both the hepatic uptake of organic solutes as well as bile salt dependent and bile salt independent canalicular excretion. Overview of the Molecular Mechanisms of Bile Formation The major transporters that determine bile formation are illustrated in Figure 1 and are discussed in greater detail in the subsequent chapters. The enrerohepatic circulation ofbile salts maintains bile salt dependent bile flow. Bile salts are excreted into bile and are largely absorbed in the terminal ileum and then efficiently removed from the portal circulation at the basolateral plasma membrane of the heparocyte. Each of these steps is dependent on the function of bile salt transport proteins.