Potential HIV Reverse Transcriptase Inhibitors | Synthesis of Benzyloxy Substituted 4,6- Diarylpyrimidine as potential HIV Reverse Transcriptase Inhibitors | Komal P. Patel (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659184710 | Verantwortliche Person f�r die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabr�ck, mail[at]preigu[dot]de | Anbieter: preigu.

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Bibliographic Details

Title

Potential HIV Reverse Transcriptase Inhibitors | Synthesis of Benzyloxy Substituted 4,6- Diarylpyrimidine as potential HIV Reverse Transcriptase Inhibitors

Publisher

LAP Lambert Academic Publishing

Publication Date

2012

Language

English

ISBN 10

3659184713

ISBN 13

9783659184710

Binding

Taschenbuch

Condition

Neu

Seller catalogs

B�cher

About this title

Synopsis

The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the prescribed limits so we proceeded with the synthesis of the compounds.

About the Author

Ms. Komal Patel has obtained her Master of Pharmacy degree in Pharmaceutical Chemistry in 2010. She has published different international and National Research paper in synthetic Chemistry, Analytical Chemistry and Drug Design.

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