The nucleus guides the life processes of the cell by directing cellular reproduction, differentiation during development, and metabolism. The study of the structure and function of the nucleus along with its genetic material serves as the foundation for the science of genetics. Principles of Nuclear Structure and Function provides a comprehensive overview of the cell nucleus by illustrating the connection between function and the architecture of the nucleus.
Richly illustrated throughout, each chapter includes an overview, detailed examples, summary points, references, and callout boxes highlighting methods and cutting-edge technology. The appendix provides a useful list of related Web sites. Some of the subjects reviewed within Principles of Nuclear Structure and Function include:
* Nuclear structure, replication, damage, and repair
* Regulation of gene expression
* The cell cycle
* Meiosis and recombination
This timely volume presents functional studies within their proper structural context and is an informative profile of the cell and molecular biology in nuclei and chromatin. For those studying cell biology, along with molecular and cell biologists, geneticists, and reproductive biologists, Principles of Nuclear Structure and Function is a definitive resource.
Visit www.wiley.com/cook for supplementary information, including additional Web resources, downloadable figures, and discussion questions.

About the Author

Peter Cook received his doctorate at The University of Oxford. As a Professor of Cell Biology at the University of Oxford and a Senior Research Fellow of Brasenose College, he teaches students of biology and medicine. His research interests include the analysis of the way chromosome structure influences gene activity. He is currently combining the techniques of molecular biology with those of high-resolution imaging to map active sites of replication and transcription within three-dimensional nuclear space. These studies have led to the surprising finding that active genes are not spread diffusely throughout the nucleus; rather, they are concentrated in discrete sites or 'factories' where the appropriate molecular machines (ie the DNA and RNA polymerases) are concentrated.

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