Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis | Symposium held in Rome/Italy, April 3-6, 1979
D. M. Conning (u. a.)
ISBN 10: 3540095845 ISBN 13: 9783540095842
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Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis | Symposium held in Rome/Italy, April 3-6, 1979 | D. M. Conning (u. a.) | Taschenbuch | viii | Englisch | 1980 | Springer Vieweg | EAN 9783540095842 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. Seller Inventory # 106366939
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N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al., 1967; Magee et al., 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al- kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely believed that DNA is the critical alkylation target. Alkylation takes place at at least 12 sites within the DNA molecule (Lawley, 1976; Singer, 1976; Pegg, 1977a). Al- though alkylation at the 7-position of guanine is the most extensive reaction with the DNA bases and provides a reliable measurement of the degree of interaction with the carcinogen (Swann and Magee, 1968, 1971), recent experiments have suggested that alkylation of oxygen atoms may be the critical reaction (Goth and Rajewsky, 1974; Margison and Kleihues, 1975; Nicoll et aI., 1975; Pegg, 1977a). These laboratories have observed a correlation between the production and persistence of 06-alkyl- guanine and the occurrence oftumors in a variety of organs of rodents exposed to N-ni- troso-carcinogens. It has, therefore, been suggested that the ability of tissues to catalyze the removal of 06-alkylguanine from DNA may provide a protective mechanism against carcinogenesis.
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Title: Quantitative Aspects of Risk Assessment in ...
Publisher: Springer Vieweg
Publication Date: 1980
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Quantative aspects of risk assessment in chemical carcinogenesis. symposium.
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24 cm. original paperback. viii,336 pp. some ills, diagrams. references. index. ISBN New York: 0387095845. "Archives of Toxicology / Archiv für Toxikologie". -(libr label, library stamps, with plasticized cover (einbandfolie), signs of use, otherwise good). 620g. Seller Inventory # 70928
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Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis : Symposium held in Rome/Italy, April 3-6, 1979
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Condition: Sehr gut. Zustand: Sehr gut | Seiten: 348 | Sprache: Englisch | Produktart: Bücher | N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al. , 1967; Magee et al. , 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely believed that DNA is the critical alkylation target. Alkylation takes place at at least 12 sites within the DNA molecule (Lawley, 1976; Singer, 1976; Pegg, 1977a). Al though alkylation at the 7-position of guanine is the most extensive reaction with the DNA bases and provides a reliable measurement of the degree of interaction with the carcinogen (Swann and Magee, 1968, 1971), recent experiments have suggested that alkylation of oxygen atoms may be the critical reaction (Goth and Rajewsky, 1974; Margison and Kleihues, 1975; Nicoll et aI. , 1975; Pegg, 1977a). These laboratories have observed a correlation between the production and persistence of 06-alkyl guanine and the occurrence oftumors in a variety of organs of rodents exposed to N-ni troso-carcinogens. It has, therefore, been suggested that the ability of tissues to catalyze the removal of 06-alkylguanine from DNA may provide a protective mechanism against carcinogenesis. Seller Inventory # 22644783/202
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Quantitative aspects of risk assessment in chemical carcinogenesis : symposium held in Rome/Italy, April 3 - 6, 1979 / ed. by J. Clemmesen . Techn. ed. A. Waring / Archives of toxicology / Supplement ; 3
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ISBN 10: 3540095845
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Softcover. VII, 336 S. : 64 Ill. u. graph. Darst. ; 25 cm Good condition. Reading pages are very clean and without marks. Retired library exemplar. Slight traces of storage or usage. Otherwise very good exemplar. 9783540095842 Sprache: Englisch Gewicht in Gramm: 649 Softcover reprint of the original 1st ed. 1980. Seller Inventory # 205652
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Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Dose Response Relationship in Long-Term Exposure to Low Levels of Carcinogens in Animals.- Epidemiological Studies of Occupational Carcinogens.- Incidence of Hepato-Carcinoma in Relation to Aflatoxin Intake.- Epidemiological Studies of Medically Used Drugs. Seller Inventory # 4880536
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Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis
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Springer Berlin Heidelberg, Springer Berlin Heidelberg Jun 1980, 1980
ISBN 10: 3540095845
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al. , 1967; Magee et al. , 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely believed that DNA is the critical alkylation target. Alkylation takes place at at least 12 sites within the DNA molecule (Lawley, 1976; Singer, 1976; Pegg, 1977a). Al though alkylation at the 7-position of guanine is the most extensive reaction with the DNA bases and provides a reliable measurement of the degree of interaction with the carcinogen (Swann and Magee, 1968, 1971), recent experiments have suggested that alkylation of oxygen atoms may be the critical reaction (Goth and Rajewsky, 1974; Margison and Kleihues, 1975; Nicoll et aI. , 1975; Pegg, 1977a). These laboratories have observed a correlation between the production and persistence of 06-alkyl guanine and the occurrence oftumors in a variety of organs of rodents exposed to N-ni troso-carcinogens. It has, therefore, been suggested that the ability of tissues to catalyze the removal of 06-alkylguanine from DNA may provide a protective mechanism against carcinogenesis. 348 pp. Englisch. Seller Inventory # 9783540095842
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Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis : Symposium held in Rome/Italy, April 3-6, 1979
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Springer Berlin Heidelberg, Springer Vieweg, 1980
ISBN 10: 3540095845
ISBN 13: 9783540095842
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al. , 1967; Magee et al. , 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely believed that DNA is the critical alkylation target. Alkylation takes place at at least 12 sites within the DNA molecule (Lawley, 1976; Singer, 1976; Pegg, 1977a). Al though alkylation at the 7-position of guanine is the most extensive reaction with the DNA bases and provides a reliable measurement of the degree of interaction with the carcinogen (Swann and Magee, 1968, 1971), recent experiments have suggested that alkylation of oxygen atoms may be the critical reaction (Goth and Rajewsky, 1974; Margison and Kleihues, 1975; Nicoll et aI. , 1975; Pegg, 1977a). These laboratories have observed a correlation between the production and persistence of 06-alkyl guanine and the occurrence oftumors in a variety of organs of rodents exposed to N-ni troso-carcinogens. It has, therefore, been suggested that the ability of tissues to catalyze the removal of 06-alkylguanine from DNA may provide a protective mechanism against carcinogenesis. Seller Inventory # 9783540095842
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Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis
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Springer Berlin Heidelberg, Springer Vieweg Jun 1980, 1980
ISBN 10: 3540095845
ISBN 13: 9783540095842
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al. , 1967; Magee et al. , 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely believed that DNA is the critical alkylation target. Alkylation takes place at at least 12 sites within the DNA molecule (Lawley, 1976; Singer, 1976; Pegg, 1977a). Al though alkylation at the 7-position of guanine is the most extensive reaction with the DNA bases and provides a reliable measurement of the degree of interaction with the carcinogen (Swann and Magee, 1968, 1971), recent experiments have suggested that alkylation of oxygen atoms may be the critical reaction (Goth and Rajewsky, 1974; Margison and Kleihues, 1975; Nicoll et aI. , 1975; Pegg, 1977a). These laboratories have observed a correlation between the production and persistence of 06-alkyl guanine and the occurrence oftumors in a variety of organs of rodents exposed to N-ni troso-carcinogens. It has, therefore, been suggested that the ability of tissues to catalyze the removal of 06-alkylguanine from DNA may provide a protective mechanism against carcinogenesis.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 348 pp. Englisch. Seller Inventory # 9783540095842
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Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis: Symposium held in Rome/Italy, April 3-6, 1979 (Archives of Toxicology, 3)
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Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis
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Condition: New. Print on Demand pp. 348 64 Figures, 67:B&W 6.69 x 9.61 in or 244 x 170 mm (Pinched Crown) Perfect Bound on White w/Gloss Lam. Seller Inventory # 44786725
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