RNA Modification, Volume 425 (Methods in Enzymology)

ISBN 10: 0123741556 / ISBN 13: 9780123741554

Published by Academic Press, 2007

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Bibliographic Details

• Title: RNA Modification, Volume 425 (Methods in Enzymology)
• Publisher: Academic Press
• Publication Date: 2007
• Language: English
• ISBN 10: 0123741556
• ISBN 13: 9780123741554
• Binding: Hardcover
• Condition: Good
• Dust Jacket Condition: Dust Jacket Included
• Book Type: book

About this title

Synopsis

The presence of modified nucleotides in cellular RNAs has been known for decades and over 100 distinct RNA modifications have been characterized to date. While the exact role of many of these modifications is still unclear, many are highly conserved across evolution and most contribute to the overall fitness of the organism. In recent years, new methods and bioinformatics approaches have been developed for the dissection of modification pathways and functions. These methods intersect a number of related fields, ranging from RNA processing to comparative genomics and systems biology. In addition, many of the techniques described in this volume have broad applicability, particularly in regards to the isolation, characterization, and reconstitution of ribonucleoprotein complexes, expanding the experimental repertoire available to all RNA researchers.

About the Author

Jonatha Gott works in the Center for RNA Molecular Biology at Case Western Reserve University, Cleveland, Ohio, USA.