Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives

Language: English

Published by LAP LAMBERT Academic Publishing Mai 2020, 2020

6202557079 / 9786202557078

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This item is printed on demand - Print on Demand Titel. Neuware -The book emphasizes the methods that chemists use to conduct their research and design the new series of 3,3-diphenyl propionic acid derivatives were synthesized The key intermediate 3,3-diphenylpropionyl chloride was synthesized by the reaction of 3,3-diphenyl propionic acid and thionyl chloride. The intermediate was further subjected to reaction with various aromatic secondary amines in the presence of NaOH in acetone. After synthesis of compounds, the synthesized compounds were characterized by their IR, 1HNMR, Mass spectral data, and elemental analysis. These derivatives were screened for their analgesic activity (Hot plate and tail flick method) and anti-inflammatory activity (Carrageen induced rat paw edema method) by using Diclofenac sodium and Indomethacin as standard drugs, respectively. The compounds AK-5 and AK-3 exhibited significantly potent anti-inflammatory and analgesic activity (two to three times) when a comparison was made with the control group. The response of promising compound (AK-5) for analgesic and anti-inflammatory action was highest among all the test compounds and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium).VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 104 pp. Englisch.

Seller Inventory # 9786202557078

Title
Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives
Author
Punet Kumar
Publisher
LAP LAMBERT Academic Publishing Mai 2020
Publication year
2020
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6202557079
ISBN 13
9786202557078
Item weight
173 grams
Dimensions
220x150x7 mm

buchversandmimpf2000

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