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Published by Editions Notre Savoir, 2025
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Language: Polish
Published by Wydawnictwo Nasza Wiedza, 2025
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Language: Portuguese
Published by Edições Nosso Conhecimento, 2025
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Published by LAP LAMBERT Academic Publishing, 2024
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Published by LAP LAMBERT Academic Publishing, 2024
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Published by LAP Lambert Academic Publishing, 2024
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Published by LAP Lambert Academic Publishing, 2024
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Published by LAP LAMBERT Academic Publishing, 2024
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Ahmad Khan Mohammad KalimDr. Mohammad Kalim Ahmad Khan, a Professor of Bioinformatics in the Department of Bioengineering at Integral University, Lucknow, India, has 16+ years of experience, 85+ publications, and has supervised six P.
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Published by Ediciones Nuestro Conocimiento, 2025
ISBN 10: 6208627656 ISBN 13: 9786208627652
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Los carcinógenos se transforman en metabolitos electrófilos, se unen al ADN y provocan cáncer a través de la activación metabólica, la desintoxicación, la angiogénesis y la metástasis. Las isozimas CYP son dianas terapéuticas en el cáncer de mama inducido por DBP. La LBVS, el acoplamiento molecular, las simulaciones MD y los estudios in vitro se han centrado en CYP1A1, 1A2 y 1B1. La LBVS identificó los hits, los refinó utilizando los filtros RO5 y ADMET de Lipinski y los acopló utilizando AutoDock4. CHEMBL1, CHEMBL2 y CHEMBL3 mostraron afinidades de unión superiores a ANF. La estabilidad se confirmó mediante simulaciones MD. El filtrado ADMET arrojó resultados no tóxicos, con ANA8430692 y ANA7923580 mostrando una estabilidad óptima. La dinámica molecular y los ensayos de inhibición enzimática validaron su potencial como inhibidores del CYP. Los análogos diseñados ANA6917483, ANA8430692 y ANA6451816 mostraron fuertes patrones de unión e interacción, lo que sugiere un potencial anticancerígeno. Este estudio mejora nuestra comprensión de la prevención del cáncer de mama inducida por DBP.
Language: Spanish
Published by Ediciones Nuestro Conocimiento, 2025
ISBN 10: 6208627656 ISBN 13: 9786208627652
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Los carcinógenos se transforman en metabolitos electrófilos, se unen al ADN y provocan cáncer a través de la activación metabólica, la desintoxicación, la angiogénesis y la metástasis. Las isozimas CYP son dianas terapéuticas en el cáncer de mama inducido por DBP. La LBVS, el acoplamiento molecular, las simulaciones MD y los estudios in vitro se han centrado en CYP1A1, 1A2 y 1B1. La LBVS identificó los hits, los refinó utilizando los filtros RO5 y ADMET de Lipinski y los acopló utilizando AutoDock4. CHEMBL1, CHEMBL2 y CHEMBL3 mostraron afinidades de unión superiores a ANF. La estabilidad se confirmó mediante simulaciones MD. El filtrado ADMET arrojó resultados no tóxicos, con ANA8430692 y ANA7923580 mostrando una estabilidad óptima. La dinámica molecular y los ensayos de inhibición enzimática validaron su potencial como inhibidores del CYP. Los análogos diseñados ANA6917483, ANA8430692 y ANA6451816 mostraron fuertes patrones de unión e interacción, lo que sugiere un potencial anticancerígeno. Este estudio mejora nuestra comprensión de la prevención del cáncer de mama inducida por DBP.
Language: French
Published by Editions Notre Savoir, 2025
ISBN 10: 6208627664 ISBN 13: 9786208627669
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Language: Polish
Published by Wydawnictwo Nasza Wiedza, 2025
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Published by Edições Nosso Conhecimento, 2025
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Published by Wydawnictwo Nasza Wiedza, 2025
ISBN 10: 6208627680 ISBN 13: 9786208627683
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Language: Portuguese
Published by Edições Nosso Conhecimento, 2025
ISBN 10: 620862763X ISBN 13: 9786208627638
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Published by Wydawnictwo Nasza Wiedza, 2025
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Published by Edições Nosso Conhecimento, 2025
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