Bender Kevin J (9 results)

paperback. Condition: Very Good. Cover and edges may have some wear.

Paperback. Condition: New. SCN2A encodes a voltage-gated sodium channel (designated NaV1.2) vital for generating neuronal action potentials. Pathogenic SCN2A variants are associated with a diverse array of neurodevelopmental disorders featuring neonatal or infantile onset epilepsy, developmental delay, autism, intellectual disability and movement disorders. SCN2A is a high confidence risk gene for autism spectrum disorder and a commonly discovered cause of neonatal onset epilepsy. This remarkable clinical heterogeneity is mirrored by extensive allelic heterogeneity and complex genotype-phenotype relationships partially explained by divergent functional consequences of pathogenic variants. Emerging therapeutic strategies targeted to specific patterns of NaV1.2 dysfunction offer hope to improving the lives of individuals affected by SCN2A-related disorders. This Element provides a review of the clinical features, genetic basis, pathophysiology, pharmacology and treatment of these genetic conditions authored by leading experts in the field and accompanied by perspectives shared by affected families. This title is also available as Open Access on Cambridge Core.…

Condition: New.

Paperback. Condition: New. SCN2A encodes a voltage-gated sodium channel (designated NaV1.2) vital for generating neuronal action potentials. Pathogenic SCN2A variants are associated with a diverse array of neurodevelopmental disorders featuring neonatal or infantile onset epilepsy, developmental delay, autism, intellectual disability and movement disorders. SCN2A is a high confidence risk gene for autism spectrum disorder and a commonly discovered cause of neonatal onset epilepsy. This remarkable clinical heterogeneity is mirrored by extensive allelic heterogeneity and complex genotype-phenotype relationships partially explained by divergent functional consequences of pathogenic variants. Emerging therapeutic strategies targeted to specific patterns of NaV1.2 dysfunction offer hope to improving the lives of individuals affected by SCN2A-related disorders. This Element provides a review of the clinical features, genetic basis, pathophysiology, pharmacology and treatment of these genetic conditions authored by leading experts in the field and accompanied by perspectives shared by affected families. This title is also available as Open Access on Cambridge Core.…

Condition: New.

Condition: New.

Hardcover. Condition: Fine. Dust Jacket Condition: Fine. 1st Edition. 1st edition, 1st printing ; xi, 612 p. : col. ill. ; 31 cm.; ISBN: 061815907X; 9780618159079 ; Dewey: 635.9 ; OCLC: 61225501 ; green cloth in color photographic dustjacket ; "Provides information on growing trees, perennials, annuals, grasses, herbs, and bulbs, features the basics of garden design, and talks about environmentally sound controls of pests and diseases" ; Contents: Creating a garden -- Thinking about your garden -- A gardener's look at plants -- Thinking about design -- Elements in the landscape -- Special gardens -- Gallery of plants -- Encyclopedia of plants -- Growing healthy plants -- Soil -- Planting -- Increasing your own plants -- Ongoing care -- Lawns.; more than 3,000 species detailed, photo gallery of 1,000 of the best trees, shrubs, perennials, annuals, bulbs, herbs, succulents, and ferns best suited to the American garden, cross-referenced ; major section on creating a garden, illustrated with 200 photographs of garden scenes; complete guide to making and maintaining a garden, with analyzing soils, somposting, buying plans, propagating, pruning, watering, fertilizing ; a chapter on pests and diseases recommends only safe, organic controls ; heavy, thick volume ; slight wear to top of dustjacket ; else FINE/FINE. Book. …

Condition: New. Print on Demand.

Condition: New. PRINT ON DEMAND.