Carsten Ehrhardt (22 results)

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Hardcover. Condition: Good. 1st Edition. Good+. Oversized hardcover, xxii + 696pp + 4 pages of glossy colour plates, NOT ex-library. Printed in the USA. Book shows limited wear, some internal creases, faint marks from reading; interior remains clean with unmarked text, free of inscriptions and stamps. Scuff-marks on upper spine. Issued without a dust jacket. -- Contents: 1 Perfused Organ Level/In Situ Techniques: - Models for Skin Absorption & Skin Toxicity Testing [Skin Structure & Function; Strategies for Skin Invasion Testing Classified According to Their Resemblance of the In Vivo Situation; Testing on Skin Toxicity]; Models of the Small Intestine [Theoretical Models Describing Gastrointestinal Absorption of Drugs; In Situ & In Vivo Models]; Drug Absorption from the Colon In Situ [In Situ Rat Colon Model for Absorption Evaluation; Permeability Characteristics of the Rat Colonic Membrane]; In Vivo & In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosa [Buccal Mucosa Structure & Environment; Buccal Mucosa Barriers; Mechanisms Involved in Oral Mucosal Absorption; Methods Employed to Assess the Permeability of the Buccal Mucosa]; In Situ & Ex Vivo Nasal Models for Preclinical Drug Development Studies [Advantages & Limitations for Drug Absorption and Metabolism Studies; Specific Applications in Nasal Drug Delivery Studies; Correlation Between Nasal Drug Absorption Models]; Isolated Perfused Lung for Drug Absorption Studies [Respiratory Drug Delivery]; 2 Cellular Level: In Vitro Models of Epithelial & Endothelial Barriers: -- Investigations of Buccal Drug Permeation & Metabolism; Screening Models to Assess Intestinal Drug Absorption & Metabolism; Cellular Models for Nasal Drug Absorption Studies [Nasal Cavity Structure & Physiology; Factors Affecting Nasal Absorption; Transport Routes of Nasal Epithelial Barrier; Models for Nasal Drug Transport & Absorption Studies]; Tracheo-Bronchial Epithelium Models [Epithelial Barriers Use in Biopharmaceutical Research]; Alveolar Epithelial Barrier Models; Cell Culture Models of the Corneal Epithelium & Reconstructed Cornea Equivalents for In Vitro Drug Absorption Studies [Human Cornea Anatomy & Physiology; Transcorneal Drug Absorption into the Eye; Corneal Cell Culture Models; Organotypic Equivalents]; Conjunctival Barrier in Ocular Drug Delivery [Introduction to the Ocular Surface & Relative Contribution of the Conjunctiva; Trans- & Sub-Conjunctival Ocular Drug Delivery; Conjunctival Disorders Overview; Models for Studying Conjunctival Transport Properties]; Inner Blood/Retinal Barrier: Transport Biology & Methodology [Conditionally Immortalized Cell Lines as a Novel (Uptake Studies); In Vivo Blood-to-Retina Influx Transport; In Vivo Vitreous/Retina-to-Blood Efflux Transport (Microdialysis Study); Ex Vivo Transporter Gene Expression Levels at the Inner Blood/Retinal Barrier (Magnetic Isolation of Retinal Vascular Endothelial Cells); Mechanism of Drug Transport at the Inner Blood/Retinal Barrier]; Regulation of Paracellular Permeability in Low-Resistance Human Vaginal-Cervical Epithelia; In Vitro Models & Multidrug Resistance Mechanisms of the Placental Barrier; Blood/Brain Barrier Function; High-Throughput Screening Using Caco-2 Cell & PAMPA Systems; Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations; 3 Bioinformatics: In Silico Tools to Predict Drug Absorption: -- Modeling Transdermal Absorption; 4 Molecular/Sub-Cellular Level: Mechanistic Tools: -- Impact of Drug Transport Proteins; Cloning & Functional Heterologous Expression of Transporters; Pharmacology of Caveolae; Immortalization Strategies for Epithelial Cells in Primary Culture; Binding-Uptake Studies & Cellular Targeting; 5 Regulatory Considerations: -- Drug Permeability Studies in Regulatory Biowaiver Applications; App: Lab Protocols (available online, updated semi-annually, as required).

Hardcover. Condition: New.

Condition: Gut. Zustand: Gut | Seiten: 724 | Sprache: Englisch | Produktart: Bücher | In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening.Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.

Condition: New. In.

Taschenbuch. Condition: Neu. Drug Absorption Studies | In Situ, In Vitro and In Silico Models | Carsten Ehrhardt (u. a.) | Taschenbuch | xxii | Englisch | 2016 | Springer | EAN 9781489977540 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening.Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.

Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening.Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.

Paperback. Condition: Brand New. reprint edition. 696 pages. 10.00x7.01x1.45 inches. In Stock.

Hardcover. Condition: Brand New. 1st edition. 696 pages. 10.50x7.50x1.50 inches. In Stock.

Hardcover. Condition: Like New. Like New. Ships from Multiple Locations. book.

Condition: new. Questo è un articolo print on demand.

Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Comprehensively summarises the different approaches to assess drug absorption from in vitro modelsGives a review on the current state-of-the-art in pharmaceutical cell biologyProvides readers with helpful protocols for many applications tha.

Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Comprehensively summarises the different approaches to assess drug absorption from in vitro modelsGives a review on the current state-of-the-art in pharmaceutical cell biologyProvides readers with helpful protocols for many applications tha.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is a well thought-out, highly practical text covering contemporary 'in vitro' techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside. 724 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is a well thought-out, highly practical text covering contemporary 'in vitro' techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside. 724 pp. Englisch.

Buch. Condition: Neu. Drug Absorption Studies | In Situ, In Vitro and In Silico Models | Kwang-Jin Kim (u. a.) | Buch | xxii | Englisch | 2008 | Humana | EAN 9780387749006 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu Print on Demand.

Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Ideal material for a huge range of professionals in drug therapeutics and research, this is a well thought-out, highly practical text covering contemporary 'in vitro' techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 724 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening.Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 724 pp. Englisch.