Giraldi Tullio (97 results)

Condition: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,650grams, ISBN:0306436671.

Paperback. Condition: new. Paperback. More than 25 years have elapsed since the development of the seminal idea which led to the synthesis of dimethyl triazenes as antitumor agents. The original suggestion of Shealy et ale was to use 4-imidazone-carboxarnide as the carrier of a nitro- gen-containing cytotoxic function. 5-diazoimidazole-4-carbox- amide (diazo-IC) was synthesized and tested in mice as a potential inhibitor of de novo purine biosynthesis. Its lack of antitumor action was attributed to its polarity and to the resulting poor uptake of this hydrophilic chemical. Diazo-IC was then coupled with dimethylamine, yielding 5, (3,3-dimethyl- l-triazeno)imidazole-4-carboxamide) (DTIC) with the intention of obtaining a less polar and more lipophil~c prod rug which might release diazo-IC intracellularly. Preliminary tests showed that DTIC had good antiumor activity in experimental systems. Further tests demonstrated a broad spectrum of action against rodent tumors, and clinical trials indicated activity against human malignancies.Subsequent clinical use of DTIC has demonstrated its usefulness against malignant melanoma, for which it is currently the drug of choice, and its effective- ness in combination chemotherapy in the treatment of other human cancers. Because of its antitumor activity the mechan- ism of action of DTIC has been investigated in some detail. The original rationale for its development, that is, the hydrolysis in vivo to diazo-IC, has been shown not to be in- volved in th-e-mechansims of action. DTIC requires metabolic acti- vation before it exerts its biological effects. Chemical Biological and Clinical Aspects. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…

Condition: NUOVO. Bologna, Il Mulino cm.15x22, pp.248, brossura. Collana Psicologia in Pratica. La mindfulness è un costrutto psicologico e al tempo stesso una pratica meditativa che ha suscitato un vivo interesse in tutti gli ambiti del benessere e della salute mentale. Moltissime sono le iniziative che vanno sotto questa etichetta e che promettono benefici a tutti i livelli: dal sollievo allo stress alla soluzione di problemi psicopatologici importanti. Tutto questo ha creato molte aspettative e ha visto un fiorire di percorsi da un lato, e di interi approcci psicoterapeutici basati sulla mindfulness dall'altro, con particolare riferimento all'area cognitivo-comportamentale. Ma la mindfulness è davvero efficace? Va bene per tutti gli ambiti del disagio psicologico? In questo volume l'autore offre un'approfondita e articolata risposta su come, in quali casi e in quali condizioni gli approcci orientati alla mindfulness sono efficaci nella psicoterapia. Uno strumento per tutti i professionisti, psicologi e psicoterapeuti, per migliorare l'efficacia della terapia e sapere quando, ovvero con quali patologie, e come inserire interventi orientati alla mindfulness nella propria attività clinica.…

Condition: New. In English.

PF. Condition: New.

Hardcover. Condition: New. 1st Edition. US SELLER SHIPS FAST FROM USA.

Condition: new.

Condition: NEW.

Condition: New. In English.

paperback. Condition: As New. Brossura editoriale di 120 pagine. Copia in condizioni pari al nuovo -- Dopo il Prozac, la cosiddetta "pillola della felicità", gli antidepressivi sono ormai giunti alla terza generazione. Ma nella gamma degli strumenti con cui si affronta oggi la malattia mentale, qual è la rilevanza degli psicofarmaci? Sono sempre e comunque efficaci? Il libro conduce il lettore lungo il percorso che dalla medicina antica porta alla nascita della medicina scientifica, illustrando il fenomeno della depressione in psichiatria, l'avvento della psicofarmacologia, con le sue luci ed ombre, sino alle più recenti esperienze di intervento psicoterapeutico in alternativa o in associazione con quello farmacoterapico. Book.…

Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - More than 25 years have elapsed since the development of the seminal idea which led to the synthesis of dimethyl triazenes as antitumor agents. The original suggestion of Shealy et ale was to use 4-imidazone-carboxarnide as the carrier of a nitro gen-containing cytotoxic function. 5-diazoimidazole-4-carbox amide (diazo-IC) was synthesized and tested in mice as a potential inhibitor of de novo purine biosynthesis. Its lack of antitumor action was attributed to its polarity and to the resulting poor uptake of this hydrophilic chemical. Diazo-IC was then coupled with dimethylamine, yielding 5, (3,3-dimethyl l-triazeno)imidazole-4-carboxamide) (DTIC) with the intention of obtaining a less polar and more lipophil~c prod rug which might release diazo-IC intracellularly. Preliminary tests showed that DTIC had good antiumor activity in experimental systems. Further tests demonstrated a broad spectrum of action against rodent tumors, and clinical trials indicated activity against human malignancies. Subsequent clinical use of DTIC has demonstrated its usefulness against malignant melanoma, for which it is currently the drug of choice, and its effective ness in combination chemotherapy in the treatment of other human cancers. Because of its antitumor activity the mechan ism of action of DTIC has been investigated in some detail. The original rationale for its development, that is, the hydrolysis in vivo to diazo-IC, has been shown not to be in volved in th-e-mechansims of action. DTIC requires metabolic acti vation before it exerts its biological effects.…

Condition: New.

Condition: New.

Condition: New. In English.

Paperback. Condition: new. Paperback. More than 25 years have elapsed since the development of the seminal idea which led to the synthesis of dimethyl triazenes as antitumor agents. The original suggestion of Shealy et ale was to use 4-imidazone-carboxarnide as the carrier of a nitro- gen-containing cytotoxic function. 5-diazoimidazole-4-carbox- amide (diazo-IC) was synthesized and tested in mice as a potential inhibitor of de novo purine biosynthesis. Its lack of antitumor action was attributed to its polarity and to the resulting poor uptake of this hydrophilic chemical. Diazo-IC was then coupled with dimethylamine, yielding 5, (3,3-dimethyl- l-triazeno)imidazole-4-carboxamide) (DTIC) with the intention of obtaining a less polar and more lipophil~c prod rug which might release diazo-IC intracellularly. Preliminary tests showed that DTIC had good antiumor activity in experimental systems. Further tests demonstrated a broad spectrum of action against rodent tumors, and clinical trials indicated activity against human malignancies.Subsequent clinical use of DTIC has demonstrated its usefulness against malignant melanoma, for which it is currently the drug of choice, and its effective- ness in combination chemotherapy in the treatment of other human cancers. Because of its antitumor activity the mechan- ism of action of DTIC has been investigated in some detail. The original rationale for its development, that is, the hydrolysis in vivo to diazo-IC, has been shown not to be in- volved in th-e-mechansims of action. DTIC requires metabolic acti- vation before it exerts its biological effects. Chemical Biological and Clinical Aspects. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability.…

Taschenbuch. Condition: Neu. Triazenes | Chemical, Biological, and Clinical Aspects | Tullio Giraldi (u. a.) | Taschenbuch | viii | Englisch | 2012 | Springer | EAN 9781461367109 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Condition: New.

Condition: New. 2017. Hardcover. . . . . .

Condition: New.

Condition: New. In English.

Condition: New. In English.

Hardcover. Condition: Brand New. 202 pages. 8.50x6.00x0.75 inches. In Stock.

Condition: New. 2017. Hardcover. . . . . . Books ship from the US and Ireland.

Hardcover. Condition: Brand New. 236 pages. 9.61x6.69x0.56 inches. In Stock.

Condition: New.

Condition: New.

Gebunden. Condition: New. KlappentextA class of antitumor agents is discussed in 16 papers, which include explorations of the synthesis, chemical properties, biotransformation, and pharmacokinetics in animals and humans, and studies of analogous agents and substa.

Condition: New. pp. 238.

Condition: New. pp. XV, 238 1 illus. 1st ed. 2019 edition NO-PA16APR2015-KAP.

Taschenbuch. Condition: Neu. Unhappiness, Sadness and 'Depression' | Antidepressants and the Mental Disorder Epidemic | Tullio Giraldi | Taschenbuch | xiv | Englisch | 2018 | Springer | EAN 9783319862187 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …