Hettich Moritz M (6 results)
Language: English
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
- Softcover
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Language: English
Published by Südwestdeutscher Verlag für Hochschulschriften, 2015
- Softcover
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Taschenbuch. Condition: Neu. Role of neuronal IGF-1R signaling in Alzheimer's disease | Involvement in development and progression | Moritz M. Hettich | Taschenbuch | 116 S. | Englisch | 2015 | Südwestdeutscher Verlag für Hochschulschriften | EAN 9783838128788 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengeriche…r Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.
Role of neuronal IGF-1R signaling in Alzheimer's disease: Involvement in development and progression
Language: English
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
- Softcover
Seller: Mispah books, Redhill, SURRE, United KingdomMispah books
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Language: English
Published by Südwestdeutscher Verlag Für Hochschulschriften Sep 2011, 2011
- Softcover
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Brains from patients with AD reveal a markedly down regulaton of IGF-1R expression and these changes progress with severity of neurodegeneration. To investigate the role of neuronal IGF-1R signaling in AD a neuron-specific IGF-1R de…ficient mice were generated and were crossed with mice expressing mutated human APP which was found in a Swedish family with early-onset AD. The offsprings of these mice were analysed. Kaplan-Meier-analysis after 60 weeks of observation revealed that nIGF-1R knockout mice were protected against premature mortality of AD mice and showed reduced Abeta accumulation. In addition Abeta plaque burden in animals with neuronal IGF-1R deletion was also reduced compared to AD animals. Taken together IGF-1R mediated signals influence APP processing leading to reduced Abeta accumulation and amyloid plaque burden. Thus, downregulation of IGF-1R observed in brain of patients suffering from Alzheimer's disease is most likely a compensatory phenomenon. 116 pp. Englisch.
Language: English
Published by Südwestdeutscher Verlag Für Hochschulschriften Sep 2011, 2011
- Softcover
- Print on Demand
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Brains from patients with AD reveal a markedly down regulaton of IGF-1R expression and these changes progress with severity of neurodegeneration. To investigate the role of neuronal IGF-1R signaling in AD a neuron-specific IGF-1R defici…ent mice were generated and were crossed with mice expressing mutated human APP which was found in a Swedish family with early-onset AD. The offsprings of these mice were analysed. Kaplan-Meier-analysis after 60 weeks of observation revealed that nIGF-1R knockout mice were protected against premature mortality of AD mice and showed reduced A¿ accumulation. In addition A¿ plaque burden in animals with neuronal IGF-1R deletion was also reduced compared to AD animals. Taken together IGF-1R mediated signals influence APP processing leading to reduced A¿ accumulation and amyloid plaque burden. Thus, downregulation of IGF-1R observed in brain of patients suffering from Alzheimer¿s disease is most likely a compensatory phenomenon.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch.
Language: English
Published by Südwestdeutscher Verlag Für Hochschulschriften, 2011
- Softcover
- Print on Demand
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Brains from patients with AD reveal a markedly down regulaton of IGF-1R expression and these changes progress with severity of neurodegeneration. To investigate the role of neuronal IGF-1R signaling in AD a neuron-specific IGF-1R deficie…nt mice were generated and were crossed with mice expressing mutated human APP which was found in a Swedish family with early-onset AD. The offsprings of these mice were analysed. Kaplan-Meier-analysis after 60 weeks of observation revealed that nIGF-1R knockout mice were protected against premature mortality of AD mice and showed reduced Abeta accumulation. In addition Abeta plaque burden in animals with neuronal IGF-1R deletion was also reduced compared to AD animals. Taken together IGF-1R mediated signals influence APP processing leading to reduced Abeta accumulation and amyloid plaque burden. Thus, downregulation of IGF-1R observed in brain of patients suffering from Alzheimer's disease is most likely a compensatory phenomenon.
