Condition: acceptable. Ausreichend/Acceptable: Exemplar mit vollständigem Text und sämtlichen Abbildungen oder Karten. Schmutztitel oder Vorsatz können fehlen. Einband bzw. Schutzumschlag weisen unter Umständen starke Gebrauchsspuren auf. / Describes a book or dust jacket that has the complete text pages (including those with maps or plates) but may lack endpapers, half-title, etc. (which must be noted). Binding, dust jacket (if any), etc may also be worn.
Condition: good. Befriedigend/Good: Durchschnittlich erhaltenes Buch bzw. Schutzumschlag mit Gebrauchsspuren, aber vollständigen Seiten. / Describes the average WORN book or dust jacket that has all the pages present.
Seller: ThriftBooks-Dallas, Dallas, TX, U.S.A.
Hardcover. Condition: Very Good. No Jacket. Missing dust jacket; May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend Less.
Seller: Midtown Scholar Bookstore, Harrisburg, PA, U.S.A.
hardcover. Condition: Very Good. No DJ as issued. No dust jacket. Very Good hardcover with light shelfwear - NICE! Standard-sized.
Seller: Gate City Books, GREENSBORO, NC, U.S.A.
Condition: good. USED book in GOOD condition. Great binding, pages and cover show normal signs of wear from use.
Seller: Big River Books, Powder Springs, GA, U.S.A.
Condition: good. This book is in good condition. The cover has minor creases or bends. The binding is tight and pages are intact. Some pages may have writing or highlighting.
US$ 3.20
Quantity: 1 available
Add to basketSoftcover. Condition: Bon. Ancien livre de bibliothèque. Edition 2009. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Good. Former library book. Edition 2009. Ammareal gives back up to 15% of this item's net price to charity organizations.
US$ 3.20
Quantity: 1 available
Add to basketSoftcover. Condition: Bon. Ancien livre de bibliothèque. Edition 2009. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Good. Former library book. Edition 2009. Ammareal gives back up to 15% of this item's net price to charity organizations.
US$ 3.20
Quantity: 1 available
Add to basketSoftcover. Condition: Bon. Ancien livre de bibliothèque. Edition 2009. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Good. Former library book. Edition 2009. Ammareal gives back up to 15% of this item's net price to charity organizations.
US$ 3.69
Quantity: 1 available
Add to basketSoftcover. Condition: Très bon. Ancien livre de bibliothèque avec équipements. Edition 2002. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 2002. Ammareal gives back up to 15% of this item's net price to charity organizations.
US$ 30.60
Quantity: 1 available
Add to basketCondition: Fair. Volume 1. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In fair condition, suitable as a study copy. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,900grams, ISBN:9780387098333.
US$ 4.26
Quantity: 1 available
Add to basketSoftcover. Condition: Bon. Ancien livre de bibliothèque avec équipements. Edition 2007. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Good. Former library book. Edition 2007. Ammareal gives back up to 15% of this item's net price to charity organizations.
US$ 4.78
Quantity: 1 available
Add to basketSoftcover. Condition: Bon. Ancien livre de bibliothèque avec équipements. Edition 2009. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Good. Former library book. Edition 2009. Ammareal gives back up to 15% of this item's net price to charity organizations.
US$ 4.78
Quantity: 1 available
Add to basketSoftcover. Condition: Bon. Ancien livre de bibliothèque avec équipements. Edition 2010. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Good. Former library book. Edition 2010. Ammareal gives back up to 15% of this item's net price to charity organizations.
Language: German
Published by Berlin / Heidelberg / New York u. a., Springer,, 2004
ISBN 10: 3540212329 ISBN 13: 9783540212324
Seller: Antiquariat Neue Kritik, Frankfurt am Main, Germany
ill. OBroschur. Condition: Gut. Fünfte, verbesserte Auflage. XVI, 610 Seiten mit 162 Abbildungen und 25 Tabellen. (= Springer-Lehrbuch). Rücken mit Leseknick, sonst kaum Gebrauchsspuren, guter Zustand. Sprache: Deutsch Gewicht in Gramm: 1950.
Language: German
Published by Berlin , Heidelberg , New York , Barcelona , Budapest , Hongkong , London , Mailand , Paris , Singapur , Tokio : Springer,, 1999
ISBN 10: 3540650539 ISBN 13: 9783540650539
Orig.-Broschur; Condition: Gut. 2., verb. Aufl. XIII, 592 S., 24 cm, Seitenschnitt etwas fleckig, sonst sehr gut. /lager2 0051 ISBN: 3540650539 Sprache: Deutsch Gewicht in Gramm: 1500.
Seller: GreatBookPrices, Columbia, MD, U.S.A.
Condition: New.
Seller: GreatBookPrices, Columbia, MD, U.S.A.
Condition: As New. Unread book in perfect condition.
Hardcover. Condition: Very Good. No Jacket.
paperback. Condition: Very Good. Used - Very Good.
Language: German
Published by Spektrum Akademischer Verlag, 2012
ISBN 10: 3827423333 ISBN 13: 9783827423337
Seller: Susanne Minarik, Ettenheim, Germany
Softcover. Condition: deutliche Gebrauchsspuren. Textmarkierungen mit Bleistift und Buntstift auf ca. 38 Seiten (vor allem am Anfang des Buches)ansonsten guter Zustandleichte Lagerspuren am Cover, keine Leseknicke am Buchrücken, sauber 854.
Language: English
Published by Springer International Publishing AG, CH, 2025
ISBN 10: 3031901533 ISBN 13: 9783031901539
Seller: Rarewaves USA, OSWEGO, IL, U.S.A.
Hardback. Condition: New.
US$ 77.69
Quantity: 1 available
Add to basketCondition: Good. Your purchase helps support Sri Lankan Children's Charity 'The Rainbow Centre'. Ex-library, so some stamps and wear, but in good overall condition. Our donations to The Rainbow Centre have helped provide an education and a safe haven to hundreds of children who live in appalling conditions.
Seller: GreatBookPricesUK, Woodford Green, United Kingdom
US$ 76.30
Quantity: Over 20 available
Add to basketCondition: New.
Seller: GreatBookPricesUK, Woodford Green, United Kingdom
US$ 77.07
Quantity: Over 20 available
Add to basketCondition: As New. Unread book in perfect condition.
Seller: GreatBookPrices, Columbia, MD, U.S.A.
Condition: As New. Unread book in perfect condition.
Language: German
Published by Berlin, Heidelberg, Springer Berlin Heidelberg, 2005
ISBN 10: 3540231420 ISBN 13: 9783540231424
Seller: Antiquariat Bookfarm, Löbnitz, Germany
Softcover. Vierte, verbesserte Auflage. 282 S. Ehem. Bibliotheksexemplar mit Signatur und Stempel. GUTER Zustand, ein paar Gebrauchsspuren. Ex-library with stamp and library-signature. GOOD condition, some traces of use. 9783540231424 Sprache: Deutsch Gewicht in Gramm: 450.
Seller: Better World Books Ltd, Dunfermline, United Kingdom
US$ 103.95
Quantity: 1 available
Add to basketCondition: Very Good. Pages intact with possible writing/highlighting. Binding strong with minor wear. Dust jackets/supplements may not be included. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good.
6., überarbeitete Aufl., Springer, Berlin/Heidelberg, 2007. XVI, 610 S. mit 162 Abb. und 25 Tabellen, kartonierter Einband--- 1405 Gramm.
Seller: killarneybooks, Inagh, CLARE, Ireland
First Edition
Hardcover. Condition: Very Good. 1st Edition. Hardcover, xiv + 311 pages, NOT ex-library. Printed in Great Britain. Minor wear, great shape. Book is clean and bright with unmarked text, free of inscriptions and stamps, firmly bound. Issued without a dust jacket. -- This book provides a comprehensive guide to the planning, execution, and statistical evaluation of bioequivalence trials. It begins by establishing the foundational principles, defining bioavailability and therapeutic equivalence, and outlining the regulatory contexts in which these studies are performed for new active substances, approved products, and modified release forms. The text then details the characterization of concentration-time profiles using essential pharmacokinetic metrics for both single and multiple-dose regimens. It builds a robust statistical framework, exploring additive and multiplicative models, normal and lognormal distributions, and the core concepts of hypothesis testing, including consumer and producer risk. A significant focus is placed on the practical assessment of average bioequivalence using the standard RT/TR crossover design, with detailed coverage of analytical procedures such as analysis of variance, the two one-sided t-tests, and nonparametric alternatives. These analytical techniques are logically linked to the crucial planning stages of determining adequate statistical power and sample size, followed by guidance on the proper presentation of results for regulatory submissions. The scope expands to address more complex scenarios, including the use of Williams designs for studies involving more than two formulations, the challenges of multiplicity in dose linearity trials, and the critical analysis of pharmacokinetic interactions like drug-drug and food-drug effects. A distinguishing feature of the work is its in-depth examination of advanced concepts that go beyond simple average comparisons, thoroughly investigating population and individual bioequivalence. This section contrasts aggregate and disaggregate criteria, details the application of replicate designs, and explains moment-based and probability-based statistical procedures. The book's breadth is further demonstrated by extending the principles of equivalence assessment to clinical endpoints, covering methodologies for both parallel group and crossover designs when direct pharmacokinetic surrogates are insufficient.