John a Barranger (40 results)

Paperback. Condition: Brand New. 522 pages. 9.25x6.00x1.18 inches. In Stock.

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Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - No detailed description available for 'Concepts in Gene Therapy'.

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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Scientific progress has been rapid in lysosomal biology during the last six decades. Its application to human disease is nothing less than spectacular. In no other group of disorders has knowledge and clinical utility progressed so speedily. Recall that the organelle was described in just 1955. Since then, the biochemical alterations and storage materials were described, the enzyme deficiencies discovered, the gene coding of these glycoproteins cloned and thousands of mutations defined. These advances have resulted in highly improved diagnosis for more than 50 diseases. For five diseases, including the most common lysosomal storage disorder, molecular therapy is a reality, extremely effective and very safe. This higher plateau of medical approaches to human disease is something to which all translational scientists aspire and only a few actually witness. The relief of pain and suffering is a tribute to the ideas and work of many dedicated investigators. Much of that work is presented in this text. Despite our ability to treat some of these diseases through enzyme replacement therapy (ERT) and, accurately define different diseases that look alike, there is much to be learned about lysosomal disease. With each step up the barrier to knowledge, a new point of view is attained, a fresh perspective. Much is seen more clearly and many 'allegories of the cave' are dispelled forever. Yet, our new view demands a new vision drawing us to find better definitions of what we see. This is how it has been with lysosomal diseases.…

Hardback. Condition: New. Reprint 2020. No detailed description available for "Concepts in Gene Therapy".

Condition: New. 1997. Hardcover. . . . . .

Taschenbuch. Condition: Neu. Lysosomal Storage Disorders | John A. Barranger (u. a.) | Taschenbuch | xx | Englisch | 2010 | Humana | EAN 9781441943668 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Condition: New. pp. 584.

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Hardback. Condition: New. Reprint 2020. No detailed description available for "Concepts in Gene Therapy".

Condition: New. 1997. Hardcover. . . . . . Books ship from the US and Ireland.

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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -No detailed description available for 'Concepts in Gene Therapy'. 576 pp. Englisch.

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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. No detailed description available for Concepts in Gene Therapy .This text deals with the various aspects of gene therapy from the point of view of leading experts in their respective fields. It provides not only an overview to the various topics of gen.…

Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Describes the nature of the lysosomal dysfunction and diseases as well as potential future treatments and therapiesProvides the historical evolution of the fieldOrganized as a textbook with disease-specific chaptersInvaluable resourc.…

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Scientific progress has been rapid in lysosomal biology during the last six decades. Its application to human disease is nothing less than spectacular. In no other group of disorders has knowledge and clinical utility progressed so speedily. Recall that the organelle was described in just 1955. Since then, the biochemical alterations and storage materials were described, the enzyme deficiencies discovered, the gene coding of these glycoproteins cloned and thousands of mutations defined. These advances have resulted in highly improved diagnosis for more than 50 diseases. For five diseases, including the most common lysosomal storage disorder, molecular therapy is a reality, extremely effective and very safe. This higher plateau of medical approaches to human disease is something to which all translational scientists aspire and only a few actually witness. The relief of pain and suffering is a tribute to the ideas and work of many dedicated investigators. Much of that work is presented in this text. Despite our ability to treat some of these diseases through enzyme replacement therapy (ERT) and, accurately define different diseases that look alike, there is much to be learned about lysosomal disease. With each step up the barrier to knowledge, a new point of view is attained, a fresh perspective. Much is seen more clearly and many 'allegories of the cave' are dispelled forever. Yet, our new view demands a new vision drawing us to find better definitions of what we see. This is how it has been with lysosomal diseases. 584 pp. Englisch.…

Buch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Frontmatter -- Preface -- Contents -- I. Methods of Gene Delivery -- 1. Retroviral Vectors -- 2. Adenoviral Vectors -- 3. Herpes Simplex Virus Mediated Gene Transfer to Neurons -- 4. Adeno-Associated Viral Vectors -- 5. Virus Functions for Artificial Vectors -- 6. Targeted Gene Delivery and Expression in Hepatocytes -- 7. Particle-Mediated Gene Delivery System for Cancer Research -- II. Methods for Inactivation or Restoration of Gene Function -- 8. Gene Inactivation by Homologous Recombination - Animal Models of Plasma Lipoprotein Disorders -- 9. Potential Antisense Oligonucleotide Therapies for Neurodegenerative Diseases -- 10. Synthetic Ribozymes: The Hammerhead Ribozyme -- 11. Ribozymes as Tools for the Gene Therapist -- III. Cellular Target Systems -- 12. Gene Transfer and Transgene Expression in Hematopoietic Cells -- 13. The Liver as a Target for Gene Therapy -- 14. Gene Therapy for Gaucher Disease via Genetically Engineered Primary Myoblasts -- 15. In vivo Secretion of Therapeutic Proteins from Neo-Organs -- IV. Genetic Diseases -- 16. Gene Therapy for Cystic Fibrosis - Strategies, Problems and Perspectives -- 17. Gene Therapy for Dystrophin Deficiency -- 18. Gene Therapy For Familial Hypercholesterolemia -- 19. Therapeutic Strategies for the Lysosomal Storage Disorders -- V. Non-Genetic and Infectious Diseases -- 20. Gene Therapy for Arthritis -- 21. Gene Therapy for HIV-1 Disease -- VI. Cancer -- 22. Suicide Genes for the Treatment of Cancer -- 23. Tumor Cell Vaccines Using Genetically Modified Cells Coexpressing Cytokines and the T Cell Costimulatory Molecule B7 -- 24. Dosage Impact on Immunotherapy with Cytokine-Gene Modified Cancer Vaccines -- 25. Tumor Suppressor Gene Therapy - Growth Arrest and Programmed Cell Death -- Acknowledgement -- References -- Contributors -- IndexDe Gruyter Mouton, Genthiner Straße 13, 10785 Berlin 576 pp. Englisch.…