Klebe Gerhard (57 results)
- Hardcover
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Language: English
Published by Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Berlin, 2025
- Hardcover
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Hardcover. Condition: new. Hardcover. This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in…the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.This textbook also discusses new methods and concepts such as epigenetics, the PROTAC approach, CRISPR-Cas9 gene scissors, structural predictions from sequence, the use of artificial intelligence and new screening technologies from biophysics. It presents successes in disrupting or enhancing protein-protein interactions as a concept for drug therapy and discusses optimising drugs considering their thermodynamic as well as kinetic binding profiles .Videos via app: simply download the SN More Media app free of charge, scan a link with the play button and immediately play the video on your smartphone or tablet. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
- Hardcover
Seller: Revaluation Books, Exeter, United KingdomRevaluation Books
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Hardcover. Condition: Brand New. 714 pages. 10.98x8.26x11.22 inches. In Stock.
- Hardcover
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Condition: New. 2024th edition NO-PA16APR2015-KAP.
- Softcover
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- Hardcover
Seller: Buchpark, Trebbin, GermanyBuchpark
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Condition: Sehr gut. Zustand: Sehr gut | Seiten: 295 | Sprache: Englisch | Produktart: Bücher | In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by… means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this requestwhich is summarized in this publication.
- Hardcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structur…al biological methods. Especially in the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.This textbook also discusses new methods and concepts such as epigenetics, the PROTAC approach, CRISPR-Cas9 gene scissors, structural predictions from sequence, the use of artificial intelligence and new screening technologies from biophysics. It presents successes in disrupting or enhancing protein-protein interactions as a concept for drug therapy and discusses optimising drugs considering their thermodynamic as well as kinetic binding profiles .Videos via app: simply download the SN More Media app free of charge, scan a link with the play button and immediately play the video on your smartphone or tablet.
Language: English
Published by Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Berlin, 2025
- Hardcover
Seller: AussieBookSeller, Truganina, VIC, AustraliaAussieBookSeller
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Hardcover. Condition: new. Hardcover. This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in…the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved.This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design.This textbook also discusses new methods and concepts such as epigenetics, the PROTAC approach, CRISPR-Cas9 gene scissors, structural predictions from sequence, the use of artificial intelligence and new screening technologies from biophysics. It presents successes in disrupting or enhancing protein-protein interactions as a concept for drug therapy and discusses optimising drugs considering their thermodynamic as well as kinetic binding profiles .Videos via app: simply download the SN More Media app free of charge, scan a link with the play button and immediately play the video on your smartphone or tablet. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability.
- Hardcover
Seller: Ria Christie Collections, Uxbridge, United KingdomRia Christie Collections
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- Hardcover
Seller: GreatBookPrices, Columbia, MD, U.S.A.GreatBookPrices
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- Hardcover
Seller: California Books, Miami, FL, U.S.A.California Books
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- Hardcover
Seller: GreatBookPricesUK, Woodford Green, United KingdomGreatBookPricesUK
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- Hardcover
Seller: Kennys Bookshop and Art Galleries Ltd., Galway, GY, IrelandKennys Bookshop and Art Galleries Ltd.
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Condition: New. The first workshop on new approaches in drug design and discovery was held in March 1999, at Schloss Rauischholzhausen, near Marburg in Germany. The speakers were invited to summarize their contributions together with their impressions on the applicability of their approach. This title summerizes this request. Ed…itor(s): Klebe, Gerhard. Num Pages: 295 pages, 35 black & white illustrations, 18 colour illustrations, biography. BIC Classification: MJA; MMG; TDCW. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 235 x 155 x 19. Weight in Grams: 688. . 2000. Reprinted from perspectives in drug discovery and. Hardback. . . . .
- Softcover
Seller: preigu, Osnabrück, Germanypreigu
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Taschenbuch. Condition: Neu. Virtual Screening: An Alternative or Complement to High Throughput Screening? | Proceedings of the Workshop 'New Approaches in Drug Design and Discovery', Special Topic 'Virtual Screening', Schloß Rauischholzhausen, Germany, March 15-18, 1999 | Gerhard Klebe | Taschenbuch | xi | Englisch | 2010 | Spr…inger | EAN 9789048155842 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
- Softcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powe…rful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this requestwhich is summarized in this publication.
- Hardcover
Seller: moluna, Greven, Germanymoluna
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Gebunden. Condition: New. In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful .
- Softcover
Seller: Books Puddle, New York, NY, U.S.A.Books Puddle
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Condition: New. pp. 308.
- Hardcover
Seller: Revaluation Books, Exeter, United KingdomRevaluation Books
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Hardcover. Condition: Brand New. 295 pages. 9.75x6.75x0.75 inches. In Stock.
- Hardcover
Seller: Kennys Bookstore, Olney, MD, U.S.A.Kennys Bookstore
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Condition: New. The first workshop on new approaches in drug design and discovery was held in March 1999, at Schloss Rauischholzhausen, near Marburg in Germany. The speakers were invited to summarize their contributions together with their impressions on the applicability of their approach. This title summerizes this request. Ed…itor(s): Klebe, Gerhard. Num Pages: 295 pages, 35 black & white illustrations, 18 colour illustrations, biography. BIC Classification: MJA; MMG; TDCW. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 235 x 155 x 19. Weight in Grams: 688. . 2000. Reprinted from perspectives in drug discovery and. Hardback. . . . . Books ship from the US and Ireland.
- Hardcover
Seller: Mispah books, Redhill, SURRE, United KingdomMispah books
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hardcover. Condition: New. NEW. SHIPS FROM MULTIPLE LOCATIONS. book.
- Hardcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Buch. Condition: Neu. Neuware - In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene va…riants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this requestwhich is summarized in this publication.
- Hardcover
Seller: Mispah books, Redhill, SURRE, United KingdomMispah books
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- Hardcover
Seller: GreatBookPricesUK, Woodford Green, United KingdomGreatBookPricesUK
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- Hardcover
Seller: GreatBookPrices, Columbia, MD, U.S.A.GreatBookPrices
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- Hardcover
Seller: Mispah books, Redhill, SURRE, United KingdomMispah books
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- Hardcover
Seller: PAPER CAVALIER UK, London, United KingdomPAPER CAVALIER UK
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Condition: very good. Gently used. May include previous owner's signature or bookplate on the front endpaper, sticker on back and/or remainder mark on text block.
- Hardcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Unique work on structure-based drug design, covering multiple aspects of drug discovery and development Fully colored, many images, computer animations of 3D structures (these only in electronic form) Makes the spatial aspects of interacting molecules cle…ar to the reader, covers multiple applications and methods in drug design Structures by mode of action, no therapeutic areas Of high relevance for academia and industrial research Focus on- gene technology in drug design, omics-technologies- computational methods- experimental techniques of structure determination- multiple examples on mode of action of current drugs- ADME-tox properties in drug development- QSAR methods- combinatorial chemistry- biologicals, ribosome, targeting protein-protein interfaces.
- Hardcover
Seller: Basi6 International, Irving, TX, U.S.A.Basi6 International
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- Hardcover
Seller: medimops, Berlin, Germanymedimops
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Condition: as new. Wie neu/Like new.
Language: German
Published by Springer Fachmedien Wiesbaden, Weisbaden, 2024
- Hardcover
Seller: Grand Eagle Retail, Bensenville, IL, U.S.A.Grand Eagle Retail
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Hardcover. Condition: new. Hardcover. Die vorliegende 3. Auflage bringt das Thema Wirkstoffdesign wieder auf den aktuellen Stand der Forschung. Der Leser lernt neue Methoden in der Gentechnologie und die erweiterte Palette strukturbiologischer Verfahren kennen. Gerade die letzten 10 Jahre wurden durch Einsatz dieser Methoden vie…le komplexe Zielstrukturen wie die G-Protein gekoppelten Rezeptoren oder Ionenkanaelen aufgeklaert. Der Leser erfaehrt wie diese lange ersehnten Komplexstrukturen mit klassischen Arzneistoffen aussehen und wie die therapeutische Wirkung erzielt wird. Im Wirkstoffdesign ist die raeumliche Struktur der interagierenden Molekuele von zentraler Bedeutung. Hier liegt der Schluessel, warum ein bestimmter Wirkstoff in seiner Gestalt praktisch durch die Geometrie und den Wirkmechanismus des Zielproteins festgelegt wird. Daher wurden die Farbabbildungen in der 3. Auflage neu gestaltet und mit Videos verknuepft, die direkt ueber QR-Codes neben den Abbildungen mit ueblichen Handys oder Tablets ohne weitere Appaufgerufen werden. Die bewegten Molekueldarstellungen geben dem Leser einen leichten Zugang zum raeumlichen Verstaendnis der molekularen Strukturen und Interaktionen.Dieses Lehrbuch wurde urspruenglich von Hans-Joachim Boehm, Gerhard Klebe und Hugo Kubinyi begruendet und richtet sich an Studierende der Pharmazie, Chemie und der Biowissenschaften, aber auch an Quereinsteiger und Medizinische Chemiker in Forschungs- und Entwicklungsabteilungen der Pharmazeutischen Industrie. Es wurde mit dem Literaturpreis des Fonds der Chemischen Industrie ausgezeichnet. Konzeptionell hebt es sich sehr stark von klassischen Lehrbuechern der pharmazeutischen Chemie ab und rueckt den Weg zum neuen Arzneistoff in den Mittelpunkt. Die Auswahl der Fallbeispiele erfolgte nach didaktischen Gesichtspunkten und versucht einen weiten UEberblick ueber Methoden und Strategien zu geben ohne den Blick zurueck auf die Anfaenge dieses Arbeitsgebiet zu vergessen. So spannt sich der Bogen von der Geschichte der Arzneimittelforschung, den Wirkmechanismen der Arzneistoffe und den Methoden zur Leitstruktursuche und -optimierung ueber Strukturbestimmungsverfahren, Modelling, Molekueldynamik und QSAR-Methoden bis zum struktur- und computergestuetzten Design.In der 3. Auflage kommen neue Methoden und Konzepte wie die Epigenetik, der PROTAC-Ansatz, die CRISPR-Cas9-Genschere, Strukturvorhersagen aus der Sequenz, der Einsatz von Kuenstlicher Intelligenz und neue Screening-Technologien aus der Biophysik zur Sprache. Erfolge beim Stoeren bzw. Verstaerken von Protein-Protein-Wechselwirkungen als Konzept der Arzneistofftherapie werden vorgestellt und UEberlegungen zur Optimierung von Arzneistoffen unter Beruecksichtigung ihrer thermodynamischen wie kinetischen Bindungsprofile werden diskutiert.Videos per App: einfach die SN More Media App kostenfrei herunterladen, einen Link mit dem Play-Button scannen und sofort das video auf Smartphone oder Tablet ausspiele. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
