Michell Mario Reimer (5 results)

Taschenbuch. Condition: Neu. Neuware -Adult zebrafish, in contrast to mammals, are capable of functional spinal cord regeneration. Using immunohistochemical markers and transgenic reporter fish for motor neurons, this study demonstrates that large differentiated motor neurons are transiently lost after a spinal lesion, suggesting that these cells undergo cell death after a lesion and are replaced. Indeed, a massive and transient increase in the number of small, undifferentiated motor neurons was observed. Proliferation and lineage tracing studies indicated significant proliferation only at the spinal ventricle and that a subset of olig2 expressing ependymo-radial glial cells are the motor neuron progenitor/stem cells in the lesioned spinal cord. Overall, this study demonstrates that adult zebrafish are capable of motor neuron regeneration from endogenous progenitor/stem cells and that sonic hedgehog is an important regulator of motor neuron regeneration. This study establishes adult spinal cord lesion as a model system for motor neuron regeneration, which may ultimately help to find ways to promote motor neuron regeneration also in human conditions, such as spinal cord injury or motor neuron disease. 100 pp. Englisch.

Taschenbuch. Condition: Neu. Motor neuron regeneration in the spinal cord of adult zebrafish | (HAMILTON, 1822) | Michell Mario Reimer | Taschenbuch | 100 S. | Englisch | 2015 | Südwestdeutscher Verlag für Hochschulschriften | EAN 9783838117065 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Reimer Michell MarioDr. Michell M. Reimer is a researcher at the University ofEdinburgh, UK. His area of interest is the role ofoligodendrocyte precursor cells (such as the ependymo-radialglial cells in zebrafish) and oligodendrocyte.

Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Adult zebrafish, in contrast to mammals, are capable of functional spinal cord regeneration. Using immunohistochemical markers and transgenic reporter fish for motor neurons, this study demonstrates that large differentiated motor neurons are transiently lost after a spinal lesion, suggesting that these cells undergo cell death after a lesion and are replaced. Indeed, a massive and transient increase in the number of small, undifferentiated motor neurons was observed. Proliferation and lineage tracing studies indicated significant proliferation only at the spinal ventricle and that a subset of olig2 expressing ependymo-radial glial cells are the motor neuron progenitor/stem cells in the lesioned spinal cord. Overall, this study demonstrates that adult zebrafish are capable of motor neuron regeneration from endogenous progenitor/stem cells and that sonic hedgehog is an important regulator of motor neuron regeneration. This study establishes adult spinal cord lesion as a model system for motor neuron regeneration, which may ultimately help to find ways to promote motor neuron regeneration also in human conditions, such as spinal cord injury or motor neuron disease.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 100 pp. Englisch.

Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Adult zebrafish, in contrast to mammals, are capable of functional spinal cord regeneration. Using immunohistochemical markers and transgenic reporter fish for motor neurons, this study demonstrates that large differentiated motor neurons are transiently lost after a spinal lesion, suggesting that these cells undergo cell death after a lesion and are replaced. Indeed, a massive and transient increase in the number of small, undifferentiated motor neurons was observed. Proliferation and lineage tracing studies indicated significant proliferation only at the spinal ventricle and that a subset of olig2 expressing ependymo-radial glial cells are the motor neuron progenitor/stem cells in the lesioned spinal cord. Overall, this study demonstrates that adult zebrafish are capable of motor neuron regeneration from endogenous progenitor/stem cells and that sonic hedgehog is an important regulator of motor neuron regeneration. This study establishes adult spinal cord lesion as a model system for motor neuron regeneration, which may ultimately help to find ways to promote motor neuron regeneration also in human conditions, such as spinal cord injury or motor neuron disease.