Mobasheri Ali (43 results)

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Condition: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | 1 Introduction Ar ticular cartilage is a specialised connective tissue with unique biological and mechanical properties which depend on the structural design of the tissue and the interactions between its unique resident cells, the chondrocytes, and the extrac- lular matrix (ECM) that makes up the bulk of the tissue (Buckwalter and Mankin 1998). Chondrocytes (Fig. 1 ) are the architects of the ECM (Muir 1995), building the macromolecular framework of the ECM from three distinct classes of mac- molecules: collagens, proteoglycans, and noncollagenous proteins. Of the collagens present in articular cartilage, collagens type II, IX, and XI form a fibrillar meshwork that gives cartilage tensile stiffness and strength (Eyre 2004; Buckwalter and Mankin 1998; Kuettner et al. 1991), whereas collagen type VI forms part of the matrix im- diately surrounding the chondrocytes, enabling them to attach to the macro- lecular framework of the ECM and acting as a transducer of biomechanical and biochemical signals in the articular cartilage (Guilak et al. 2006; Roughley and Lee 1994). Embedded in the collagen mesh are large aggregating proteoglycans (agg- can), which give cartilage its stiffness to compression, its resilience and contribute to its long-term durability (Dudhia 2005; Kiani et al. 2002; Luo et al. 2000; Roughley and Lee 1994). The extracellular matrix proteins in cartilage are of great significance for the regulation of the cell behaviour, proliferation, differentiation and morphogenesis (Kosher et al. 1973; Kosher and Church 1975; von der Mark et al. 1977; Hewitt et al.…

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Taschenbuch. Condition: Neu. Facilitative Glucose Transporters in Articular Chondrocytes | Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytokines | Ali Mobasheri (u. a.) | Taschenbuch | Advances in Anatomy, Embryology and Cell Biology | vii | Englisch | 2013 | Springer | EAN 9783540788980 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Condition: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | 1 Introduction The provision of nutrients and oxygen to synovial joints is essential for the ph ysiological and load-bearing functions of articular cartilage and the hom- static control of metabolism within chondrocytes, its resident cells (Mobasheri et al. 2002c; Mobasheri et al. 2006). The transport of nutrients (i. e. , glucose, other h- ose and pentose sugars, amino acids, nucleotides, nucleosides and water soluble vitamins such as vitamin C) into articular chondrocytes is essential for the synt- sis of collagens, proteoglycans, and glycosaminoglycans by chondrocytes (Clark et al. 2002; Goggs et al. 2005; McNulty et al. 2005; Mobasheri et al. 2002a). There are numerous biological mechanisms by which nutritional factors might be expected to exert favorable influences on cartilage function and pathophysiological events in disease processes including osteoarthritis (McAlindon 2006). A decade ago, very l- tle was known about nutrient transport in chondrocytes, particularly the transport of glucose, related sugars, and water-soluble vitamins, which are essential for the synthesis of glycosaminoglycans by chondrocytes. Glucose is a crucial nutrient for cartilage function in vivo as it is for many other tissues and organs. However, it has always been assumed that glucose is important for the in vitro cultivation of chond- cytes, ex vivo maintenance of cartilage explants, and cartilage tissue engineering procedures.…

Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Integrins belong to an evolutionary conserved family of adhesion molecules with important biological functions throughout the animal kingdom. They are heterodimeric glycoproteins involved in cell-cell and cell-matrix adhesion and communication. Physiologically they function as intra- and extracellular signalling molecules in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic spread of tumor cells. Integrin beta 1 (ß1-integrin) is a multi-functional member of the integrin superfamily and is an integral protein involved in cell-matrix adhesion, cell signalling, cellular defense, cell adhesion, protein binding, protein heterodimerization and receptor-mediated activity. The ß1-integrin family of cell surface receptors appears to play a major role in mediating cell-extracellular matrix interactions that are important in regulating these fundamental processes. ß1-integrins are important adhesion molecules that are highly expressed in articular chondrocytes where they bind to extracellular matrix molecules including fibronectin, laminin, and fibrillar collagens. In addition to mediating cell adhesion, members of the ß1 subfamily of integrins contribute to the organisation of the cytoskeleton and activate numerous intracellular signal transduction pathways. Recent studies from the authors' laboratory and from other leading groups have shown that ß1-integrins are essential for cell signalling and communication in chondrocytes. Furthermore, ß1-integrins function as mechanoreceptors in the chondrocyte mechanotransduction pathway. Their expression is therefore essential for maintaining the chondrocyte phenotype, preventing chondrocyte apoptosis and regulating chondrocyte-specific gene expression. This book volume summarizes the work that the authorshave done on ß1-integrins over the last 18 years and focuses on the expression and regulation of these proteins in chondrocytes and their role in the context ofthe unique function of chondrocytes within articular cartilage.…

Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - 1 Introduction The provision of nutrients and oxygen to synovial joints is essential for the ph ysiological and load-bearing functions of articular cartilage and the hom- static control of metabolism within chondrocytes, its resident cells (Mobasheri et al. 2002c; Mobasheri et al. 2006). The transport of nutrients (i. e. , glucose, other h- ose and pentose sugars, amino acids, nucleotides, nucleosides and water soluble vitamins such as vitamin C) into articular chondrocytes is essential for the synt- sis of collagens, proteoglycans, and glycosaminoglycans by chondrocytes (Clark et al. 2002; Goggs et al. 2005; McNulty et al. 2005; Mobasheri et al. 2002a). There are numerous biological mechanisms by which nutritional factors might be expected to exert favorable influences on cartilage function and pathophysiological events in disease processes including osteoarthritis (McAlindon 2006). A decade ago, very l- tle was known about nutrient transport in chondrocytes, particularly the transport of glucose, related sugars, and water-soluble vitamins, which are essential for the synthesis of glycosaminoglycans by chondrocytes. Glucose is a crucial nutrient for cartilage function in vivo as it is for many other tissues and organs. However, it has always been assumed that glucose is important for the in vitro cultivation of chond- cytes, ex vivo maintenance of cartilage explants, and cartilage tissue engineering procedures.…

Taschenbuch. Condition: Neu. The Surfaceome | Methods and Protocols | Csaba Matta (u. a.) | Taschenbuch | Methods in Molecular Biology | xii | Englisch | 2026 | Springer | EAN 9781071644362 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume explores a collection of methodologies used to study the complexities of biological membranes and the associated surfaceome. The chapters in this book aim to facilitate the adoption of innovative methods to help researchers advance their understanding of the biology of membranes and their role in health and disease. Written in the highly successfulMethods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on trouble shooting and avoiding known pitfalls.Comprehensive and cutting-edge, The Surfaceome: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this important and developing field.…

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