Publications Medknowledge (12 results)

Taschenbuch. Condition: Neu. Neuware.

Taschenbuch. Condition: Neu. Neuware.

Paperback. Condition: new. Paperback. Critical illness rarely affects one organ in isolation. A patient with severe infection may simultaneously develop shock, respiratory failure, acute kidney injury, coagulopathy, altered consciousness, metabolic disturbances, and cardiovascular instability. Successful intensive care therefore depends on understanding how these systems interact-and knowing how to recognize deterioration, stabilize physiology, support failing organs, and continuously reassess the response to treatment. PRINCIPLES OF CRITICAL ILLNESS AND INTENSIVE CARE MEDICINE is a comprehensive clinical guide designed to build that integrated understanding. From the fundamental biology of critical illness to advanced mechanical ventilation, hemodynamic monitoring, extracorporeal support, neurocritical care, trauma, toxicology, sepsis, organ failure, and emerging technologies, this book provides a detailed yet clinically focused exploration of modern intensive care medicine. Rather than presenting ICU medicine as a collection of isolated protocols, the text emphasizes physiology, clinical reasoning, pattern recognition, and decision-making. Readers are guided through the mechanisms behind deterioration and the principles that determine when to escalate, modify, or de-escalate organ support. Inside, you will explore: 1. Initial assessment, resuscitation, and management of the deteriorating patient2. Oxygen delivery, tissue perfusion, lactate physiology, and cellular metabolism3. Acid-base, electrolyte, fluid, and metabolic emergencies4. Airway management and emergency respiratory stabilization5. Acute respiratory failure, ARDS, and advanced lung-protective ventilation6. Mechanical ventilation, ventilator waveforms, PEEP, driving pressure, and patient-ventilator interaction7. Liberation from mechanical ventilation and tracheostomy management8. Hemodynamic monitoring, fluid responsiveness, vasopressors, and inotropes9. Shock, sepsis, septic shock, and microcirculatory dysfunction10. Acute cardiac emergencies, arrhythmias, cardiac arrest, and post-resuscitation care11. Acute kidney injury and renal replacement therapy Each chapter combines advanced physiology with bedside application and includes learning objectives, key terms, clinical case studies, scenario-based questions, practical tables, memorable clinical tips, and focused chapter summaries to reinforce understanding. This book is designed for medical students, residents, critical-care trainees, physicians, nurses, respiratory therapists, advanced practice clinicians, paramedics, and other healthcare professionals seeking a deeper understanding of the critically ill patient. Whether used for structured learning, clinical revision, professional development, or bedside reference, PRINCIPLES OF CRITICAL ILLNESS AND INTENSIVE CARE MEDICINE offers a comprehensive framework for understanding one of the most complex and demanding areas of modern medicine. Critical care is not simply about supporting failing organs-it is about understanding why they are failing, how they interact, and what must be done next. This item is printed on demand. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. …

PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

Condition: New. Print on Demand.

PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

Paperback. Condition: new. Paperback. Why does one microorganism cause a mild, self-limited infection in one person but life-threatening disease in another? How do pathogens cross biological barriers, evade immune recognition, persist inside the host, and sometimes turn the immune response itself into a source of tissue injury? PRINCIPLES OF INFECTION, IMMUNITY, AND HOST-PATHOGEN INTERACTIONS provides a comprehensive and clinically integrated exploration of the complex relationship between infectious organisms and the human immune system. Designed to bridge microbiology, immunology, infectious disease, pathology, diagnostics, therapeutics, and public health, this book moves beyond isolated facts to explain the mechanisms that determine whether microbial exposure results in clearance, colonization, persistent infection, immunopathology, or severe disease. Beginning with the foundations of microbial biology and host defense, the book examines bacterial, viral, fungal, and parasitic pathogens alongside the innate and adaptive immune mechanisms responsible for recognizing and controlling them. You will explore physical and mucosal barriers, pattern-recognition receptors, phagocytes, natural killer cells, complement, antigen presentation, T-cell and B-cell responses, antibodies, immune memory, inflammation, tolerance, hypersensitivity, immunodeficiency, and immune regulation. The text then connects these mechanisms directly to microbial pathogenesis. Detailed discussions explain adhesion, colonization, invasion, toxin production, intracellular survival, biofilm formation, antigenic variation, latency, molecular mimicry, immune evasion, and the balance between direct microbial injury and immune-mediated tissue damage. You will also gain a practical understanding of modern infectious-disease diagnostics, including specimen selection, microscopy, staining, culture, antigen detection, serology, PCR, multiplex nucleic-acid amplification tests, sequencing, metagenomics, antimicrobial susceptibility testing, and interpretation of biomarkers. A dedicated section on antimicrobial therapy explores antibacterial, antiviral, antifungal, and antiparasitic treatment, pharmacokinetic and pharmacodynamic principles, mechanisms of antimicrobial resistance, multidrug-resistant organisms, stewardship, de-escalation, therapeutic monitoring, and the importance of source control. Vaccination and prevention are treated as core components of infectious-disease medicine. Topics include immune memory, vaccine platforms, population immunity, immune escape, boosting, infection-control precautions, sterilization, disinfection, outbreak investigation, surveillance, transmission dynamics, emerging infections, zoonoses, One Health, global health, and pandemic preparedness. The final chapter looks toward the future of infection and immunity, exploring precision infectious disease, host genetics, pathogen genomics, monoclonal antibodies, cytokine-targeted therapy, microbiome therapeutics, bacteriophage therapy, artificial intelligence, systems immunology, computational epidemiology, digital diagnostics, personalized vaccines, and next-generation approaches to host-pathogen science. Whether you are building a foundation in infection and immunity or strengthening advanced clinical understanding, PRINCIPLES OF INFECTION, IMMUNITY, AND HOST-PATHOGEN INTERACTIONS offers a unified framework for understanding one of medicine's most important relationships: the continuous biological contest between microorganisms and the human host. Understand the pathogen. Understand the immune response. Understand the interaction that determines disease. This item is printed on demand. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…

PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

Condition: New. Print on Demand.

Paperback. Condition: new. Paperback. Critical illness rarely affects one organ in isolation. A patient with severe infection may simultaneously develop shock, respiratory failure, acute kidney injury, coagulopathy, altered consciousness, metabolic disturbances, and cardiovascular instability. Successful intensive care therefore depends on understanding how these systems interact-and knowing how to recognize deterioration, stabilize physiology, support failing organs, and continuously reassess the response to treatment. PRINCIPLES OF CRITICAL ILLNESS AND INTENSIVE CARE MEDICINE is a comprehensive clinical guide designed to build that integrated understanding. From the fundamental biology of critical illness to advanced mechanical ventilation, hemodynamic monitoring, extracorporeal support, neurocritical care, trauma, toxicology, sepsis, organ failure, and emerging technologies, this book provides a detailed yet clinically focused exploration of modern intensive care medicine. Rather than presenting ICU medicine as a collection of isolated protocols, the text emphasizes physiology, clinical reasoning, pattern recognition, and decision-making. Readers are guided through the mechanisms behind deterioration and the principles that determine when to escalate, modify, or de-escalate organ support. Inside, you will explore: 1. Initial assessment, resuscitation, and management of the deteriorating patient2. Oxygen delivery, tissue perfusion, lactate physiology, and cellular metabolism3. Acid-base, electrolyte, fluid, and metabolic emergencies4. Airway management and emergency respiratory stabilization5. Acute respiratory failure, ARDS, and advanced lung-protective ventilation6. Mechanical ventilation, ventilator waveforms, PEEP, driving pressure, and patient-ventilator interaction7. Liberation from mechanical ventilation and tracheostomy management8. Hemodynamic monitoring, fluid responsiveness, vasopressors, and inotropes9. Shock, sepsis, septic shock, and microcirculatory dysfunction10. Acute cardiac emergencies, arrhythmias, cardiac arrest, and post-resuscitation care11. Acute kidney injury and renal replacement therapy Each chapter combines advanced physiology with bedside application and includes learning objectives, key terms, clinical case studies, scenario-based questions, practical tables, memorable clinical tips, and focused chapter summaries to reinforce understanding. This book is designed for medical students, residents, critical-care trainees, physicians, nurses, respiratory therapists, advanced practice clinicians, paramedics, and other healthcare professionals seeking a deeper understanding of the critically ill patient. Whether used for structured learning, clinical revision, professional development, or bedside reference, PRINCIPLES OF CRITICAL ILLNESS AND INTENSIVE CARE MEDICINE offers a comprehensive framework for understanding one of the most complex and demanding areas of modern medicine. Critical care is not simply about supporting failing organs-it is about understanding why they are failing, how they interact, and what must be done next. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability. …

Paperback. Condition: new. Paperback. Why does one microorganism cause a mild, self-limited infection in one person but life-threatening disease in another? How do pathogens cross biological barriers, evade immune recognition, persist inside the host, and sometimes turn the immune response itself into a source of tissue injury? PRINCIPLES OF INFECTION, IMMUNITY, AND HOST-PATHOGEN INTERACTIONS provides a comprehensive and clinically integrated exploration of the complex relationship between infectious organisms and the human immune system. Designed to bridge microbiology, immunology, infectious disease, pathology, diagnostics, therapeutics, and public health, this book moves beyond isolated facts to explain the mechanisms that determine whether microbial exposure results in clearance, colonization, persistent infection, immunopathology, or severe disease. Beginning with the foundations of microbial biology and host defense, the book examines bacterial, viral, fungal, and parasitic pathogens alongside the innate and adaptive immune mechanisms responsible for recognizing and controlling them. You will explore physical and mucosal barriers, pattern-recognition receptors, phagocytes, natural killer cells, complement, antigen presentation, T-cell and B-cell responses, antibodies, immune memory, inflammation, tolerance, hypersensitivity, immunodeficiency, and immune regulation. The text then connects these mechanisms directly to microbial pathogenesis. Detailed discussions explain adhesion, colonization, invasion, toxin production, intracellular survival, biofilm formation, antigenic variation, latency, molecular mimicry, immune evasion, and the balance between direct microbial injury and immune-mediated tissue damage. You will also gain a practical understanding of modern infectious-disease diagnostics, including specimen selection, microscopy, staining, culture, antigen detection, serology, PCR, multiplex nucleic-acid amplification tests, sequencing, metagenomics, antimicrobial susceptibility testing, and interpretation of biomarkers. A dedicated section on antimicrobial therapy explores antibacterial, antiviral, antifungal, and antiparasitic treatment, pharmacokinetic and pharmacodynamic principles, mechanisms of antimicrobial resistance, multidrug-resistant organisms, stewardship, de-escalation, therapeutic monitoring, and the importance of source control. Vaccination and prevention are treated as core components of infectious-disease medicine. Topics include immune memory, vaccine platforms, population immunity, immune escape, boosting, infection-control precautions, sterilization, disinfection, outbreak investigation, surveillance, transmission dynamics, emerging infections, zoonoses, One Health, global health, and pandemic preparedness. The final chapter looks toward the future of infection and immunity, exploring precision infectious disease, host genetics, pathogen genomics, monoclonal antibodies, cytokine-targeted therapy, microbiome therapeutics, bacteriophage therapy, artificial intelligence, systems immunology, computational epidemiology, digital diagnostics, personalized vaccines, and next-generation approaches to host-pathogen science. Whether you are building a foundation in infection and immunity or strengthening advanced clinical understanding, PRINCIPLES OF INFECTION, IMMUNITY, AND HOST-PATHOGEN INTERACTIONS offers a unified framework for understanding one of medicine's most important relationships: the continuous biological contest between microorganisms and the human host. Understand the pathogen. Understand the immune response. Understand the interaction that determines disease. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.…