Urban Laszlo (128 results)

hardcover. Condition: Very Good. Pages are clean with no markings.

Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Hardcover. Condition: Fine. Dust Jacket Condition: Fine. First Edition. Scarce first edition in Hungarian of Beckett's comic masterpiece, his first fictional work to appear in Hungarian translation. The translation is by Tandori Dezso with a 16pp introduction and footnotes by Mihalyi Gabor. There is an original Surrealist artwork on the dw by Urban Laszlo depicting a giant fly in a rocking chair. Yellow linen lettered in black, top edge stained orange. Minimal sunning to dw spine else that too is Fine. Urban Laszlo (illustrator).…

Hardcover. Condition: Very Good. Hit and Lead Profiling: Identification and Optimization of Drug-like Molecules by Bernard Faller & Laszlo Urban eds.Includes inscription to 'Humphrey' by Laszlo UrbanMethods and Principles in Medicinal Chemistry, Vol. 43The only reference on current methods to generate pharmacokinetic and safety profiles of drug candidates, as well as how they must be balanced against one other for the best selection of candidates for further development. Following a brief introduction to the necessities of filtering and risk assessment of potential new drug molecules before actual drug development, the two equally important aspects of pharmacological (ADME) and safety (toxicity) profiling are covered in sep.…

Condition: Used. pp. 410.

Condition: New. pp. 336.

Condition: Used. pp. 410.

Condition: New. pp. 336.

Condition: New.

Condition: As New. Unread book in perfect condition.

Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The research field of somatosensory processing in mammals has experienced revolutionary changes in recent years. Accumulation of basic and clinical data has greatly accelerated, and new phenomena have emerged. With the aid of new, refined methods, molecular and cellular changes have been described, underlying the signal transduction-transmission between the internal/external environment and the central nervous system have been described. The discovery of the interaction between the nervous and the immune system has, for example changed our view on the development of inflammatory diseases, while the cloning of genes encoding different trophic factors has boosted studies revealing profound changes in the regeneration of neurons, and induction of changes in phenotype. The study of the pre-and postsynaptic modulation of transmitter release, and the examination of the combined effects of amino acid and peptide transmitters has become recently possible by using cultured cell lines and in vitro techniques. Although it is in embryonic state, computational properties of single DRG cells under normal and pathological conditions are being investigated. Results soon or later will have a great impact on pain research and consequently ultimately in clinical pain management. This brief introduction indicates how our knowledge of the somatosensory system has increased dramatically recently. However, many investigators cultivate only a very specific field in the growing area of somatosensory research and find it difficult to integrate a more universal knowledge of their work.…

Condition: Used. pp. 410.

Taschenbuch. Condition: Neu. Cellular Mechanisms of Sensory Processing | The Somatosensory System | Laszlo Urban | Taschenbuch | xi | Englisch | 2011 | Springer | EAN 9783642787645 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Condition: New.

Condition: As New. Unread book in perfect condition.

Condition: New.

Paperback. Condition: Brand New. reprint edition. 513 pages. 9.25x6.10x1.30 inches. In Stock.

Condition: New. pp. 616.

Condition: New.

Condition: As New. Unread book in perfect condition.

Condition: New.

Hardback. Condition: New. This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.…

Condition: New. pp. 616.

Condition: As New. Unread book in perfect condition.

Condition: New. Provides information on drug side effects and their mitigation strategy during drug discovery, as well as guidance for risk assessment and evidence-based toxicology. Editor(s): Xu, Jinghai J.; Urban, Laszlo. Num Pages: 404 pages, 84 b/w illus. 35 tables. BIC Classification: MMG. Category: (P) Professional & Vocational. Dimension: 258 x 189 x 27. Weight in Grams: 1010. . 2010. Illustrated. hardcover. . . . . …

Condition: New. In English.

Hardback. Condition: New. With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered.…

Condition: New.

Gebunden. Condition: New. Laszlo Urban received his MD and PhD in neurophysiology/neuropharmacology in Hungary, and was visiting professor at Duke University between 1987 and 1989. He is currently global head of Preclinical Safety Profiling at the Novartis Institutes for Biomedical .