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Condition: New. pp. 126.
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US$ 88.31
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Ships from United Kingdom to U.S.A.Quantity: 2 available
Add to basketPaperback. Condition: Brand New. 1st edition. 118 pages. 8.75x6.00x0.50 inches. In Stock.
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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
Language: English
Published by Springer International Publishing, Springer, 2014
ISBN 10: 3319050257 ISBN 13: 9783319050256
Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.
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Cullin-RING Ligases and Protein Neddylation: Biology and Therapeutics (Advances in Experimental Medicine and Biology, 1217)
Book 472 of 544: Advances in Experimental Medicine and BiologySeller: Ria Christie Collections, Uxbridge, United Kingdom
Seller rating 5 out of 5 stars
US$ 189.41
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Cullin-RING Ligases and Protein Neddylation: Biology and Therapeutics (Advances in Experimental Medicine and Biology)
Book 472 of 544: Advances in Experimental Medicine and BiologySeller: Ria Christie Collections, Uxbridge, United Kingdom
Seller rating 5 out of 5 stars
US$ 189.41
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Cullin-Ring Ligases and Protein Neddylation : Biology and Therapeutics
Book 472 of 544: Advances in Experimental Medicine and BiologySeller: GreatBookPricesUK, Woodford Green, United Kingdom
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US$ 189.38
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Condition: As New. Unread book in perfect condition.
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Cullin-Ring Ligases and Protein Neddylation : Biology and Therapeutics
Book 472 of 544: Advances in Experimental Medicine and BiologySeller: GreatBookPricesUK, Woodford Green, United Kingdom
Seller rating 5 out of 5 stars
US$ 209.26
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Add to basketCondition: As New. Unread book in perfect condition.
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Condition: New. 1st ed. 2020 edition NO-PA16APR2015-KAP.
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Condition: New. pp. VIII, 372 119 illus., 68 illus. in color. 1st ed. 2020 edition NO-PA16APR2015-KAP.
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Taschenbuch. Condition: Neu. Cullin-RING Ligases and Protein Neddylation | Biology and Therapeutics | Yi Sun (u. a.) | Taschenbuch | Advances in Experimental Medicine and Biology | viii | Englisch | 2021 | Springer | EAN 9789811510274 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
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Cullin-RING Ligases and Protein Neddylation : Biology and Therapeutics
Book 472 of 544: Advances in Experimental Medicine and BiologyLanguage: English
Published by Springer Nature Singapore, Springer Nature Singapore, 2020
ISBN 10: 9811510245 ISBN 13: 9789811510243
Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.
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Cullin-ring Ligases and Protein Neddylation: Biology and Therapeutics
Book 472 of 544: Advances in Experimental Medicine and BiologyUS$ 271.56
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Add to basketPaperback. Condition: Brand New. 380 pages. 10.00x7.01x0.90 inches. In Stock.
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Cullin-ring Ligases and Protein Neddylation: Biology and Therapeutics
Book 472 of 544: Advances in Experimental Medicine and BiologyUS$ 274.40
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Add to basketHardcover. Condition: Brand New. 382 pages. 10.00x7.00x1.10 inches. In Stock.
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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
Language: English
Published by Springer International Publishing Apr 2014, 2014
ISBN 10: 3319050257 ISBN 13: 9783319050256
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers. 124 pp. Englisch.
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Condition: New. Print on Demand pp. 126 11 Illus. (Col.).
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Condition: New. PRINT ON DEMAND pp. 126.
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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
Language: English
Published by Springer International Publishing, 2014
ISBN 10: 3319050257 ISBN 13: 9783319050256
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Includes updated profiles of SCF and APC cellular functions and their characterized ubiquitin substratesIntroduces the emergent SCF family members in the human genome and summarizes phenotypes in which the adapter proteins of SCF and APC are manip.
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Condition: new. Questo è un articolo print on demand.
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Condition: new. Questo è un articolo print on demand.
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Cullin-RING Ligases and Protein Neddylation
Book 472 of 544: Advances in Experimental Medicine and BiologyLanguage: English
Published by Springer Nature Singapore Jan 2020, 2020
ISBN 10: 9811510245 ISBN 13: 9789811510243
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Seller rating 5 out of 5 stars
Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine. 380 pp. Englisch.
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Cullin-RING Ligases and Protein Neddylation
Book 472 of 544: Advances in Experimental Medicine and BiologyLanguage: English
Published by Springer Nature Singapore Jan 2021, 2021
ISBN 10: 981151027X ISBN 13: 9789811510274
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine. 380 pp. Englisch.
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Cullin-RING Ligases and Protein Neddylation
Book 472 of 544: Advances in Experimental Medicine and BiologyUS$ 161.61
US$ 56.46 shipping
Ships from Germany to U.S.A.Quantity: Over 20 available
Add to basketGebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Summarizes all the important aspects of CRLsProvides potential strategies for targeting various human diseasesWritten by pioneers in the field of ubiquitin and neddylationDr. Yi Sun.
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Cullin-RING Ligases and Protein Neddylation
Book 472 of 544: Advances in Experimental Medicine and BiologyUS$ 161.61
US$ 56.46 shipping
Ships from Germany to U.S.A.Quantity: Over 20 available
Add to basketCondition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Summarizes all the important aspects of CRLsProvides potential strategies for targeting various human diseasesWritten by pioneers in the field of ubiquitin and neddylationDr. Yi Sun.
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Cullin-RING Ligases and Protein Neddylation: Biology and Therapeutics (Advances in Experimental Medicine and Biology)
Book 472 of 544: Advances in Experimental Medicine and BiologyUS$ 246.50
US$ 8.67 shipping
Ships from United Kingdom to U.S.A.Quantity: 4 available
Add to basketCondition: New. Print on Demand.
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Cullin-RING Ligases and Protein Neddylation: Biology and Therapeutics: 1217 (Advances in Experimental Medicine and Biology)
Book 472 of 544: Advances in Experimental Medicine and BiologyUS$ 246.66
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Ships from United Kingdom to U.S.A.Quantity: 4 available
Add to basketCondition: New. Print on Demand pp. VIII, 372 119 illus., 68 illus. in color.
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Cullin-RING Ligases and Protein Neddylation
Book 472 of 544: Advances in Experimental Medicine and BiologyLanguage: English
Published by Springer, Springer Jan 2020, 2020
ISBN 10: 9811510245 ISBN 13: 9789811510243
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Buch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 380 pp. Englisch.
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Cullin-RING Ligases and Protein Neddylation
Book 472 of 544: Advances in Experimental Medicine and BiologyLanguage: English
Published by Springer, Springer Jan 2021, 2021
ISBN 10: 981151027X ISBN 13: 9789811510274
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 380 pp. Englisch.
