Calcium Waves, Gradients and Oscillations.

Bock, Gregory and Kate Ackrill:

ISBN 10: 0471952346 / ISBN 13: 9780471952343

Published by Chichester: Wiley, 1995

About this Item

Series: Novartis Foundation Symposia. ix 291p large hardback, navy laminated cloth, like new condition, no noticeable wear, tight binding and sharp corners, bright pink endpapers, pages clean and neat, free from annotation or highlighting, diagrams and photographs clear and sharp, a very good unused copy Language: English Weight (g): 580.

Seller Inventory # 234463

Bibliographic Details

• Title: Calcium Waves, Gradients and Oscillations.
• Publisher: Chichester: Wiley
• Publication Date: 1995
• Language: English
• ISBN 10: 0471952346
• ISBN 13: 9780471952343
• Binding: Hardback
• Edition: 1st Edition
• Condition: As New
• Weight: 580 grams
• Seller catalogs:
  • Biology

About this title

Synopsis

Renowned contributors provide comprehensive coverage of calcium gradients, waves and oscillations in diverse systems. Discusses the mechanisms initiating and sustaining calcium waves and their role in cell function. Describes studies using the latest techniques for measuring calcium ion gradients including chemiluminescent indicators.

From the Back Cover

Calcium Waves, Gradients and Oscillations Chairman: Michael J. Berridge 1995 Standing free gradients are widespread in living systems and changes in intracellular free Ca²⁺ concentration, [Ca²⁺]_i, are involved in controlling the responses of cells to many stimuli. Imaging techniques have revealed complex patterns of Ca²⁺ distribution arising spontaneously or after stimulation of cells by hormones or neurotransmitters. In many cells, Ca²⁺- mobilizing agonists stimulate oscillations in [Ca²⁺]_i, with the frequency of the concentration rises (‘spikes’) depending on the agonist concentration and the external Ca²⁺ concentration. The Ca²⁺ spikes are organized spatially as well as temporally, so that a regenerative wave spreads across the cell. Such Ca²⁺ waves have been observed in many cell types: in hamster eggs, fertilization stimulates a Ca²⁺ wave that spreads from the point of sperm entry to the opposite pole; in Xenopus oocytes, the Ca²⁺ signal is initiated at several foci, with the waves spreading out symmetrically to give spheres or asymmetrically to give spirals. Most of the models proposed to explain the initiation and propagation of Ca²⁺ waves involve positive feedback, with Ca²⁺ amplifying its own release through an action on phospholipase C, generating periodic surges of inositol 1,4,5-trisphosphate (InsP₃), or through Ca²⁺- induced Ca²⁺ release. Propagation seems to depend on the regenerative release of Ca²⁺ from internal stores controlled by the InsP₃ receptor or the ryanodine receptor. This book features studies of intracellular Ca²⁺ gradients, oscillations and waves in various systems. Calcium gradients are best understood in tip-growing plants cells, medaka (fish) eggs and the mould Dictyostelium. Current knowledge of the initiation, propagation, characteristics, functional consequences and physiological significance of Ca²⁺ oscillations and waves in heptocytes, in Cl^- secretion from pancreatic acinar cells, in heart muscle cells and in neurons is presented. The mechanisms, form and importance of Ca²⁺ waves in Xenopus oocytes and in mammalian fertilization are considered. The biochemical basis of Ca²⁺ signals can spread as waves from cell to cell, through the action of a secreted intermediate (ATP) or by diffusion of InsP₃ or perhaps Ca²⁺, across gap junctions; studies of this process in epithelial cells and glial cells are featured. Related Ciba Foundation Symposia: No. 183 Circadian clocks and their adjustment Chairman: J. M. Waterhouse 1995 ISBN 0 471 94305 3 No. 164 Interactions among cell signalling systems Chairman: Y. Nishizuka 1992 ISBN 0 471 93073 3