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Intracellular Traffic and Neurodegenerative Disorders (Research and Perspectives in Alzheimer's Disease) - Hardcover
Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.
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This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.
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“This monograph is an up to date account of the abnormalities in axonal transport of proteins and molecules in neurons in the aging and diseased brain. ... This book is meant for neuropathologists, neurologists, and advanced graduate students in the Neurosciences. I can recommend it for these professionals without hesitation.” (Joseph J. Grenier, Amazon.com, November, 2013)"About this title" may belong to another edition of this title.
- PublisherSpringer
- Publication date2008
- ISBN 10 3540879404
- ISBN 13 9783540879404
- BindingHardcover
- Number of pages198
- EditorSt.George-Hyslop Peter H., Mobley William C.
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Intracellular Traffic and Neurodegenerative Disorders (Research and Perspectives in Alzheimer's Disease)
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Book Description Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms.- Intramembrane Proteolysis by ?-Secretase and Signal Peptide Peptidases.- Axonal Transport and Neurodegenerative Disease.- Simple Cellular Solu. Seller Inventory # 4901741
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Book Description Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated. 200 pp. Englisch. Seller Inventory # 9783540879404
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