Characterization of Four Alternatively Spliced Casein Kinase I Alpha Isoforms (Classic Reprint) - Hardcover

Zheng Fu

9780266847045: Characterization of Four Alternatively Spliced Casein Kinase I Alpha Isoforms (Classic Reprint)

Hardcover

ISBN 10: 0266847048 ISBN 13: 9780266847045

Publisher: Forgotten Books, 2018

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Excerpt from Characterization of Four Alternatively Spliced Casein Kinase I Alpha Isoforms

Casein Kinase I (oki) is a ubiquitously expressed, second messenger-independent, serine threonine protein kinase that recognizes acidic rather than basic substrates. At this time, it is clear that cki is not a single kinase, but a family consisting of multiple isoforms. To date, both the function and the regulation of these isoforms still remain poorly understood. On the one hand, although numerous protein substrates for cki in vitro have been identified, very little is known as to whether or not these potential targets are relevant physiological substrates in vivo, and which specific cki isoform(s) may be responsible. On the other hand, the cki activity has been identified in several intracellular locations, but the isoform-specific subcellular compartmentalization is largely uncharacterized. Recently, it has been suggested that the exact localization of several yeast cki isoforms is absolutely essential for their respective functions and regulation (vancura et al.

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