Chandran Anandhakumar (20 results)
Language: English
Published by Singapore, Springer., 2018
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
Seller: Universitätsbuchhandlung Herta Hold GmbH, Berlin, GermanyUniversitätsbuchhandlung Herta Hold GmbH
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XV, 114 p. Softcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Springer Theses. Recognizing Outstanding Ph.D. Research. Sprache: Englis…ch.
Language: English
Published by Springer, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
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Condition: New. In.
Language: English
Published by Springer, 2017
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Hardcover
Seller: Ria Christie Collections, Uxbridge, United KingdomRia Christie Collections
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Condition: New. In.
Language: English
Published by Springer, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
Seller: Books Puddle, New York, NY, U.S.A.Books Puddle
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Condition: New. Softcover reprint of the original 1st ed. 2018 edition NO-PA16APR2015-KAP.
Language: English
Published by Springer Singapore, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
Seller: moluna, Greven, Germanymoluna
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Language: English
Published by Springer Singapore, 2017
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Hardcover
Seller: moluna, Greven, Germanymoluna
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Language: English
Published by Springer Verlag, 2018
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
Seller: Revaluation Books, Exeter, United KingdomRevaluation Books
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Paperback. Condition: Brand New. reprint edition. 132 pages. 9.25x6.10x0.30 inches. In Stock.
Language: English
Published by Springer Verlag, 2017
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Hardcover
Seller: Revaluation Books, Exeter, United KingdomRevaluation Books
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Hardcover. Condition: Brand New. 129 pages. 9.25x6.10x0.59 inches. In Stock.
Language: English
Published by Springer, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
Seller: preigu, Osnabrück, Germanypreigu
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Taschenbuch. Condition: Neu. Advancing Development of Synthetic Gene Regulators | With the Power of High-Throughput Sequencing in Chemical Biology | Anandhakumar Chandran | Taschenbuch | Springer Theses | xv | Englisch | 2019 | Springer | EAN 9789811348990 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr.… 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Language: English
Published by Springer, Springer, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a spe…cific genomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.
Language: English
Published by Springer Nature Singapore, 2017
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Hardcover
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific g…enomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.
Language: English
Published by Springer, 2017
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Hardcover
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Seller: Basi6 International, Irving, TX, U.S.A.Basi6 International
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Condition: Brand New. New. US edition. Print on demand title. Delivery takes 20-25 days.
Language: English
Published by Springer, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
- Print on Demand
Seller: Basi6 International, Irving, TX, U.S.A.Basi6 International
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Condition: Brand New. New. US edition. Print on demand title. Delivery takes 20-25 days.
Language: English
Published by Springer, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
- Print on Demand
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Condition: new. Questo è un articolo print on demand.
Language: English
Published by Springer, 2017
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Hardcover
- Print on Demand
Seller: Brook Bookstore On Demand, Napoli, NA, ItalyBrook Bookstore On Demand
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Condition: new. Questo è un articolo print on demand.
Language: English
Published by Springer Nature Singapore Jan 2019, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
- Print on Demand
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules… targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence. 132 pp. Englisch.
Language: English
Published by SPRINGER NATURE Sep 2017, 2017
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Hardcover
- Print on Demand
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules target…ing a specific genomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence. 114 pp. Englisch.
Language: English
Published by Springer, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
- Print on Demand
Seller: Majestic Books, Hounslow, United KingdomMajestic Books
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Language: English
Published by Springer, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
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Seller: Biblios, frankfurt am main, HESSE, GermanyBiblios
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Language: English
Published by Springer, Springer Jan 2019, 2019
Series: Springer Theses, Book 343 of 797. Book 343 of 797 - Springer Theses
- Softcover
- Print on Demand
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Nominated by Kyoto University as an outstanding Ph.D. thesisSpringer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 132 pp. Englisch.
